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An mTORC1‐Dependent Mouse Model for Cardiac Sarcoidosis

2023; Wiley; Volume: 12; Issue: 19 Linguagem: Inglês

10.1161/jaha.123.030478

2047-9980

Carlos Bueno‐Betí, Clarice X. Lim, Alexandros Protonotarios, Petra Lujza Szabó, Joseph Westaby, Mario Mazic, Mary N. Sheppard, Elijah R. Behr, Ouafa Hamza, Attila Kiss, Bruno K. Podesser, Markus Hengstschläger, Thomas Weichhart, Angeliki Asimaki,

Eosinophilic Disorders and Syndromes

Background Sarcoidosis is an inflammatory, granulomatous disease of unknown cause affecting multiple organs, including the heart. Untreated, unresolved granulomatous inflammation can lead to cardiac fibrosis, arrhythmias, and eventually heart failure. Here we characterize the cardiac phenotype of mice with chronic activation of mammalian target of rapamycin (mTOR) complex 1 signaling in myeloid cells known to cause spontaneous pulmonary sarcoid-like granulomas. Methods and Results The cardiac phenotype of mice with conditional deletion of the