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Time-restricted feeding combined with resistance exercise prevents obesity and improves lipid metabolism in the liver of mice fed a high-fat diet

2023; American Physiological Society; Volume: 325; Issue: 5 Linguagem: Inglês

10.1152/ajpendo.00129.2023

1522-1555

Robson Damasceno de Lima, Renan Fudoli Lins Vieira, Vitor Rosetto Muñoz, Amandine Chaix, Ana Paula Azevêdo Macêdo, Gabriel Calheiros Antunes, Maíra Felonato, Renata Rosseto Braga, Susana Castelo Branco Ramos Nakandakari, Rafael Calais Gaspar, Adelino Sánchez Ramos da Silva, Dennys E. Cintra, Leandro Pereira de Moura, Rania A. Mekary, Eduardo R. Ropelle, José Rodrigo Pauli,

Diet and metabolism studies

Nonalcoholic fatty liver disease (NAFLD), a condition characterized by the accumulation of fat in the liver, is estimated to be the most common liver disease worldwide. Obesity is a major risk factor and contributor, and, accordingly, weight loss can improve NAFLD. Previous studies in preclinical models of diet-induced obesity and fatty liver disease have shown the independent benefits of resistance exercise training (RT) and time-restricted feeding (TRF) in preventing weight gain and hepatic build-up of fat. Here, we tested the combined effect of TRF and RT on obesity and NAFLD in mice fed a high-fat diet. Our results showed that both TRF-8-h food access in the active phase-and RT-consisting of three weekly sessions of ladder climbing-attenuated body weight gain, improved glycemic homeostasis, and decreased the accumulation of lipids in the liver. TRF combined with RT improved the respiratory exchange rate, energy expenditure, and mitochondrial respiration in the liver. Furthermore, gene expression analysis in the liver revealed lower mRNA expression of lipogenesis and inflammation genes along with increased mRNA of fatty acid oxidation genes in the TRF + RT group. Importantly, combined TRF + RT was shown to be more efficient in preventing obesity and metabolic disorders. In conclusion, TRF and RT exert complementary actions compared with isolated interventions, with significant effects on metabolic disorders and NAFLD in mice.