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Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila

2023; Frontiers Media; Volume: 15; Linguagem: Inglês

10.3389/fnagi.2023.1223911

1663-4365

Jonathan R. Roth, Ruan Carlos Macêdo de Moraes, Brittney P. Xu, Savannah R. Crawley, Malghalara A. Khan, Girish C. Melkani,

Genetics, Aging, and Longevity in Model Organisms

Huntington's disease (HD) is a neurodegenerative disease characterized by movement and cognitive dysfunction. HD is caused by a CAG expansion in exon 1 of the