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GWAS Meta-Analysis of Suicide Attempt: Identification of 12 Genome-Wide Significant Loci and Implication of Genetic Risks for Specific Health Factors

2023; American Psychiatric Association; Volume: 180; Issue: 10 Linguagem: Inglês

10.1176/appi.ajp.21121266

1535-7228

Anna R. Docherty, Niamh Mullins, Allison E. Ashley‐Koch, Xuejun Qin, Jonathan R. I. Coleman, Andrey A. Shabalin, Jooeun Kang, Balasz Murnyak, Frank R. Wendt, Mark J. Adams, Adrián I. Campos, Emily DiBlasi, Janice M. Fullerton, Henry R. Kranzler, Amanda V. Bakian, Eric T. Monson, Miguel E. Rentería, Consuelo Walss‐Bass, Ole A. Andreassen, Chittaranjan Behera, Cynthia M. Bulik, Howard J. Edenberg, Ronald C. Kessler, J. John Mann, John I. Nürnberger, Giorgio Pistis, Fabian Streit, Robert J. Ursano, Renato Polimanti, Michelle F. Dennis, Melanie E. Garrett, Lauren P. Hair, Philip D. Harvey, Elizabeth R. Hauser, Michael A. Hauser, Jennifer E. Huffman, Daniel Jacobson, Ravi Madduri, Benjamin H. McMahon, David W. Oslin, Jodie A. Trafton, Swapnil Awasthi, Wade H. Berrettini, Martin Bohus, Xiao Chang, Hsi‐Chung Chen, Wei J. Chen, Erik D. Christensen, Scott J. Crow, Philibert Duriez, Alexis C. Edwards, Fernando Fernández‐Aranda, Hanga Galfalvy, Michael J. Gandal, Philip Gorwood, Yiran Guo, Jonathan D. Hafferty, Hákon Hákonarson, Katherine A. Halmi, Akitoyo Hishimoto, Sonia Jain, Stéphane Jamain, Susana Jiménez‐Múrcia, Craig Johnson, Allan S. Kaplan, Walter H. Kaye, Pamela K. Keel, James L. Kennedy, Minsoo Kim, Kelly L. Klump, Daniel F. Levey, Dong Li, Shih‐Cheng Liao, Klaus Lieb, Lisa Lilenfeld, Christian R. Marshall, James E. Mitchell, Satoshi Okazaki, Ikuo Otsuka, Dalila Pinto, Abigail Powers, Nicolás Ramoz, Stephan Ripke, Stefan Roepke, Vsevolod Rozanov, Stephen W. Scherer, Christian Schmahl, Marcus Sokolowski, Anna Starnawska, Michael Strober, Mei‐Hsin Su, Laura M. Thornton, Janet Treasure, Erin B. Ware, Hunna J. Watson, Stephanie H. Witt, D. Blake Woodside, Zeynep Yılmaz, Lea Zillich, Rolf Adolfsson, Ingrid Agartz, Martin Alda, Lars Alfredsson, Vivek Appadurai, María Soler Artigas, Sandra Van der Auwera, M.H. Azevedo, Nicholas Bass, Claiton H.D. Bau, Bernhard T. Baune, Frank Bellivier, Kenneth I. Berger, Joanna M. Biernacka, Tim B. Bigdeli, Elisabeth B. Binder, Michael Boehnke, Marco P. Boks, David Braff, Richard A. Bryant, Monika Budde, Enda M. Byrne, Wiepke Cahn, Enrique Castelao, Jorge A. Cervilla, Boris Chaumette, Aiden Corvin, Nicholas Craddock, Srdjan Djurovic, Jerome C. Foo, Andreas J. Forstner, Mark A. Frye, Justine M. Gatt, Ina Giegling, Hans J. Grabe, Melissa J. Green, Eugênio H. Grevet, Maria Grigoroiu‐Serbânescu, Blanca Gutiérrez, José Guzmán‐Parra, Marian L. Hamshere, Annette M. Hartmann, Joanna Hauser, Stefanie Heilmann‐Heimbach, Per Hoffmann, Marcus Ising, Ian Jones, Lisa Jones, Lina Jönsson, René S. Kahn, John R. Kelsoe, Kenneth S. Kendler, Stefan Kloiber, Karestan C. Koenen, Manolis Kogevinas, Marie‐Odile Krebs, Mikael Landén, Marion Leboyer, Phil H. Lee, Douglas F. Levinson, Calwing Liao, Jolanta Lissowska, Fermín Mayoral, Susan L. McElroy, Patrick J. McGrath, Peter McGuffin, Andrew McQuillin, Divya Mehta, Ingrid Melle, Philip B. Mitchell, Esther Molina, Gunnar Morken, Caroline M. Nievergelt, Markus M. Nöthen, Michael O’Donovan, Roel A. Ophoff, Michael J. Owen, Carlos N. Pato, Michele T. Pato, Brenda W.J.H. Penninx, James B. Potash, Robert A. Power, Martin Preisig, Digby Quested, Josep Antoni Ramos‐Quiroga, Andreas Reif, Marta Ribasés, Vanesa Richarte, Marcella Rietschel, Margarita Rivera, Andrea L. Roberts, Gloria Roberts, Guy A. Rouleau, Diego Luiz Rovaris, Alan R. Sanders, Peter R. Schofield, Thomas G. Schulze, Laura J. Scott, Alessandro Serretti, Jianxin Shi, Lea Sirignano, Pamela Sklar, Olav B. Smeland, Jordan W. Smoller, Edmund Sonuga‐Barke, Maciej Trzaskowski, Ming T. Tsuang, Gustavo Turecki, Laura Vilar‐Ribó, John B. Vincent, Henry Völzke, James Walters, Cynthia Shannon Weickert, Thomas W. Weickert, Myrna M. Weissman, Leanne M. Williams, Naomi R. Wray, Clement C. Zai, Esben Agerbo, Anders D. Børglum, Gerome Breen, Ditte Demontis, Annette Erlangsen, Joel Gelernter, Stephen J. Glatt, David M. Hougaard, Hai‐Gwo Hwu, Po‐Hsiu Kuo, Cathryn M. Lewis, Qingqin S. Li, Chih‐Min Liu, Nicholas G. Martin, Andrew M. McIntosh, Sarah E. Medland, Ole Mors, Merete Nordentoft, Catherine M. Olsen, David J. Porteous, Daniel J. Smıth, Eli A. Stahl, Murray B. Stein, Danuta Wasserman, Thomas Werge, David C. Whiteman, Virginia L. Willour, Hilary Coon, Jean C. Beckham, Nathan A. Kimbrel, Douglas M. Ruderfer,

Forensic and Genetic Research

Suicidal behavior is heritable and is a major cause of death worldwide. Two large-scale genome-wide association studies (GWASs) recently discovered and cross-validated genome-wide significant (GWS) loci for suicide attempt (SA). The present study leveraged the genetic cohorts from both studies to conduct the largest GWAS meta-analysis of SA to date. Multi-ancestry and admixture-specific meta-analyses were conducted within groups of significant African, East Asian, and European ancestry admixtures.