Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Progressive multifocal leukoencephalopathy triggered by COVID-19 in a previously asymptomatic person living with undiagnosed HIV infection

2023; Elsevier BV; Volume: 137; Linguagem: Inglês

10.1016/j.ijid.2023.09.020

1878-3511

Yago Marcos Pessoa-Gonçalves, Thaís Soares Farnesi-de-Assunção, Marlos Aureliano Dias de Sousa, Luis Marcos Ferreira, Beatriz Sodré Matos, Anna Victória Bernardes e Borges, Ana Carolina de Morais Oliveira-Scussel, Alex Eduardo da Silva, Carlo José Freire Oliveira, Marcos Silva, Virmondes Rodrigues,

Multiple Sclerosis Research Studies

This report presents the case of a 47-year-old male patient who worked as a mathematics teacher and experienced the sudden onset of disorientation, aphasia, and acalculia during an online class. The current study reveals the first documented case of Human Immunodeficiency Virus and Progressive Multifocal Leukoencephalopathy with the detection of SARS-CoV-2 and Human Polyomavirus 2 (previously known as John Cunningham Virus) in the cerebrospinal fluid. Furthermore, serum analysis revealed elevated concentrations of IL-6, IL-17, and IL-8, which are potential factors known to reduce the expression of tight junctions and adhesion molecules in the extracellular matrix, thereby affecting the permeability of the blood-brain barrier. Finally, the study discusses whether SARS-CoV-2 triggers or exacerbates PML.