Portal de Periódicos da CAPES

Pancreatic Cancer-Secreted Proteins: Targeting Their Functions in Tumor Microenvironment

2023; Multidisciplinary Digital Publishing Institute; Volume: 15; Issue: 19 Linguagem: Inglês

10.3390/cancers15194825

2072-6694

Anna Lisa Cammarota, Antonia Falco, Anna Basile, Carlo Molino, Massimiliano Chetta, Gianni D’Angelo, Liberato Marzullo, Margot De Marco, Maria Caterina Turco, Alessandra Rosati,

Cancer Research and Treatments

Pancreatic Ductal Adenocarcinoma (PDAC) is a ravaging disease with a poor prognosis, requiring a more detailed understanding of its biology to foster the development of effective therapies. The unsatisfactory results of treatments targeting cell proliferation and its related mechanisms suggest a shift in focus towards the inflammatory tumor microenvironment (TME). Here, we discuss the role of cancer-secreted proteins in the complex TME tumor-stroma crosstalk, shedding lights on druggable molecular targets for the development of innovative, safer and more efficient therapeutic strategies.