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Amyloid PET across the cognitive spectrum in former professional and college American football players: findings from the DIAGNOSE CTE Research Project

2023; BioMed Central; Volume: 15; Issue: 1 Linguagem: Inglês

10.1186/s13195-023-01315-5

1758-9193

Robert A. Stern, Diana Trujillo‐Rodriguez, Yorghos Tripodis, Surya Pulukuri, Michael L. Alosco, Charles H. Adler, Laura J. Balcer, Charles Bernick, Zachary Baucom, Kenneth Marek, Michael D. McClean, Keith A. Johnson, Ann C. McKee, Thor D. Stein, Jesse Mez, Joseph Palmisano, Jeffrey L. Cummings, Martha E. Shenton, Eric M. Reiman, Kewei Chen, Hillary Protas, Yi Su, Connie Boker, Rhoda Au, Robert C. Cantu, Lindsay A. Farrer, Robert Helm, Douglas I. Katz, Neil W. Kowall, Gustavo Mercier, James Otis, Jason Weller, Tahlia Bragg, Irene Simkin, Suzan van Amerongen, Alondra Andino, Shannon E. Conneely, Courtney Diamond, Tessa Fagle, Olivia Haller, Tennyson Hunt, Nicole Gullotti, Bailey Kossow, Carrie Kugelmass, Megan Mariani, Brian Mayville, Kathleen McLaughlin, Mary Nanna, Marty DiPopolo, Taylor Platt, Fiona Rice, Madison Sestak, Douglas S. Annis, Christine E. Chaisson, Diane Dixon, Carolyn Finney, Kerrin Gallagher, Kaitlin Hartlage, Jun Lü, Brett Martin, EO Ojo, Brittany Pine, Janani Ramachandran, Fatima Tuz‐Zahra, Eukyung Yhang, Sylvain Bouix, Jennifer Fitzsimmons, Alexander P. Lin, Inga K. Koerte, Ofer Pasternak, Hector Arciniega, Tashrif Billah, Elena M. Bonke, Katherine M. Breedlove, Holly Carrington, Eduardo Coello, Michael J. Coleman, Omar John, Leonard Jung, Huijun Liao, Maria Loy, Elizabeth Rizzoni, Vivian Schultz, Annelise Silva, Brynn Vessey, Tim L. T. Wiegand, Sarah J. Banks, Jason Miller, Aaron Ritter, Marwan N. Sabbagh, Raelynn de la Cruz, Jan Durant, Morgan Golceker, Nicolette Harmon, Jaeson Kaylegian, Rachelle Long, Christin Nance, Priscilla Sandoval, Miranda Staples, Robert Turner, Emma F. Clark, Andrew Serrano, David W. Dodick, Yonas E. Geda, Jennifer V. Wethe, Amy Duffy, Bryce W. Falk, Marci Howard, Michelle Montague, Thomas Osgood, Debra Babcock, Patrick S.F. Bellgowan, William Barr, Judith D. Goldberg, Binu Joseph, Ivan I. Kirov, Yvonne W. Lui, Charles R. Marmar, Thomas Wısnıewskı, Alhassan Al-Kharafi, Allan George, Lisena Hasanaj, Sammie Martin, Edward P. Riley, William Runge, Liliana Serrano, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Jeffrey J. Iliff, Gail Li, Deidre Janssen, James S. Meabon, Elaine R. Peskind, Juan Piantino, Abigail G. Schindler, Ronald G. Thomas, Elizabeth A. Colasurdo, Jane B. Shofer, Daniel S. Marcus, Jenny Gurney, Richard M. Greenwald,

Advanced MRI Techniques and Applications

Exposure to repetitive head impacts (RHI) in American football players can lead to cognitive impairment and dementia due to neurodegenerative disease, particularly chronic traumatic encephalopathy (CTE). The pathognomonic lesion of CTE consists of perivascular aggregates of hyper-phosphorylated tau in neurons at the depths of cortical sulci. However, it is unclear whether exposure to RHI accelerates amyloid-β (Aβ) plaque formation and increases the risk for Alzheimer's disease (AD). Although the Aβ neuritic plaques characteristic of AD are observed in a minority of later-stage CTE cases, diffuse plaques are more common. This study examined whether former professional and college American football players, including those with cognitive impairment and dementia, have elevated neuritic Aβ plaque density, as measured by florbetapir PET. Regardless of cognitive and functional status, elevated levels of florbetapir uptake were not expected.