A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s disease
2023; Elsevier BV; Volume: 30; Issue: 10 Linguagem: Inglês
10.1016/j.stem.2023.08.011
ISSN1934-5909
AutoresYongjin Yoo, Gernot Neumayer, Yohei Shibuya, Marius Marc-Daniel Mader, Marius Wernig,
Tópico(s)Neurological Disease Mechanisms and Treatments
Resumo(Cell Stem Cell 30, 1043–1053.e1–e6; August 3, 2023) In the originally published version of this manuscript, the author Marius Marc-Daniel Mader was mistakenly listed with “Marc-Daniel Mader” as the surname, when in fact “Mader” is the correct surname of this author and “Marc-Daniel” is the middle name. This has now been corrected in the article online. A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer’s diseaseYoo et al.Cell Stem CellAugust 03, 2023In BriefMutations of the microglial receptor TREM2 leads to a premature neurodegeneration syndrome, and specific genetic variants are associated with Alzheimer’s disease. Yoo et al. show that high-efficiency microglia replacement represents a promising cell therapy to restore Trem2 function in a Trem2-dependent Alzheimer’s disease mouse model. Full-Text PDF
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