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The role of miRNAs in multiple sclerosis pathogenesis, diagnosis, and therapeutic resistance

2023; Elsevier BV; Volume: 251; Linguagem: Inglês

10.1016/j.prp.2023.154880

1618-0631

Ahmed S. Doghish, Ola Elazazy, Hend H. Mohamed, Reda Mansour, Aml Ghanem, Ahmed Hassan Ibrahim Faraag, Mohammed S. Elballal, Mahmoud A. Elrebehy, Ahmed E. Elesawy, Sherif S. Abdel Mageed, Osama A. Mohammed, Yara A. Nassar, Ahmed I. Abulsoud, Ahmed Amr Raouf, Mustafa Ahmed Abdel‐Reheim, Ahmed A. Rashad, Alaa S. Elawady, Ahmed Mohammed M Elsisi, Ali Alsalme, Mohamed A. Ali,

RNA Interference and Gene Delivery

In recent years, microRNAs (miRNAs) have gained increased attention from researchers around the globe. Although it is twenty nucleotides long, it can modulate several gene targets simultaneously. Their mal expression is a signature of various pathologies, and they provide the foundation to elucidate the molecular mechanisms of each pathology. Among the debilitating central nervous system (CNS) disorders with a growing prevalence globally is the multiple sclerosis (MS). Moreover, the diagnosis of MS is challenging due to the lack of disease-specific biomarkers, and the diagnosis mainly depends on ruling out other disabilities. MS could adversely affect patients' lives through its progression, and only symptomatic treatments are available as therapeutic options, but an exact cure is yet unavailable. Consequently, this review hopes to further the study of the biological features of miRNAs in MS and explore their potential as a therapeutic target.