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The type‐I interferon response potentiates seeded tau aggregation and exacerbates tau pathology

2023; Wiley; Volume: 20; Issue: 2 Linguagem: Inglês

10.1002/alz.13493

1552-5279

Sophie Sanford, Lauren V. C. Miller, Marina Vaysburd, Sophie Keeling, Benjamin J. Tuck, Jessica Clark, Michal Neumann, Victoria Syanda, Leo C. James, William A. McEwan,

Tryptophan and brain disorders

Abstract INTRODUCTION Signatures of a type‐I interferon (IFN‐I) response are observed in the post mortem brain in Alzheimer's disease (AD) and other tauopathies. However, the effect of the IFN‐I response on pathological tau accumulation remains unclear. METHODS We examined the effects of IFN‐I signaling in primary neural culture models of seeded tau aggregation and P301S‐tau transgenic mouse models in the context of genetic deletion of the IFN‐I receptor (IFNAR). RESULTS Polyinosinic:polycytidylic acid (PolyI:C), a synthetic analog of viral nucleic acids, evoked a potent cytokine response that enhanced seeded aggregation of tau in an IFN‐I‐dependent manner. IFN‐I‐induced vulnerability could be pharmacologically prevented and was intrinsic to neurons. Aged P301S‐tau mice lacking Ifnar1 had significantly reduced tau pathology compared to mice with intact IFN signaling. DISCUSSION We identify a critical role for IFN‐I in potentiating tau aggregation. IFN‐I is therefore identified as a potential therapeutic target in AD and other tauopathies. Highlights Type‐I IFN (IFN‐I) promotes seeded tau aggregation in neural cultures. IFNAR inhibition prevents IFN‐I driven sensitivity to tau aggregation. IFN‐I driven vulnerability is intrinsic to neurons. Tau pathology is significantly reduced in aged P301S‐tau mice lacking IFNAR.