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Assessing cognitive decline in the aging brain: lessons from rodent and human studies

2023; Volume: 9; Issue: 1 Linguagem: Inglês

10.1038/s41514-023-00120-6

2731-6068

David V.C. Brito, Filipa Esteves, Ana Teresa Rajado, Nádia Silva, Rossana M. C. Andrade, Joana Apolónio, Sofia M. Calado, Maria Leonor Faleiro, Carlos A. Matos, Nuno Marques, Ana Marreiros, Hipólito Nzwalo, Sandra Pais, Isabel Palmeirim, Vânia Palma Roberto, Sónia Simão, Natércia Joaquim, Rubén Miranda, António Pêgas, D. Raposo, Attilio Di Spiezio Sardo, Inês M. Araújo, José Bragança, Pedro Castelo‐Branco, Clévio Nóbrega,

Diet and metabolism studies

Abstract As life expectancy continues to increase worldwide, age-related dysfunction will largely impact our societies in the future. Aging is well established to promote the deterioration of cognitive function and is the primary risk factor for the development of prevalent neurological disorders. Even in the absence of dementia, age-related cognitive decline impacts specific types of memories and brain structures in humans and animal models. Despite this, preclinical and clinical studies that investigate age-related changes in brain physiology often use largely different methods, which hinders the translational potential of findings. This review seeks to integrate what is known about age-related changes in the brain with analogue cognitive tests used in humans and rodent studies, ranging from “pen and paper” tests to virtual-reality-based paradigms. Finally, we draw parallels between the behavior paradigms used in research compared to the enrollment into clinical trials that aim to study age-related cognitive decline.