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Persistent headaches one year after bacterial meningitis: prevalence, determinants and impact on quality of life

2023; Springer Science+Business Media; Volume: 42; Issue: 12 Linguagem: Inglês

10.1007/s10096-023-04673-y

1435-4373

Rémi Nguyen Van, Sarah Tubiana, T. de Broucker, Cédric Joseph, Carine Roy, Marie‐Caroline Meyohas, Thiérry Prazuck, Catherine Chirouze, Bruno Hoen, Xavier Duval, Matthieu Revest, Bruno Mourvillier, Marie-Cécile Ploy, François Caron, Pierre‐Édouard Bollaert, Olivier Gaillot, Muhamed‐Kheir Taha, Claire Poyart, Stéphane Bonacorsi, François Vandenesch, Emmanuelle Cambau, Marc Lecuit, Alain Gravet, Bruno Frachet, D Lévy-Brühl, François Raffi, Marie Préau, Nadia Anguel, Laurent Argaud, S. Arista, Laurence Armand-Lefevre, Stéphanie Balavoine, Régine Baraduc, Guilène Barnaud, Guillaume Béraud, Louis Bernard, Georges Bernars, Dominique Bertei, Emilie Bessède, Typhaine Billard Pomares, Charlotte Biron, Stéphane Bland, J. Boileau, Patrice Boubeau, Sandra Bourdon, Aurore Bousquet, Sophie Boyer, A. Bozorg–Grayeli, Laurent Bret, Cédric Bretonnière, François Bricaire, Elsa Brocas, Michel Brun, J. Buret, Christophe Burucoa, Jean Cabalion, Mathieu Cabon, G. Camuset, Christophe Canevet, François Caron, Anne Carricajo, Bernard Castan, Eric Caumes, Charles Cazanave, Amélie Chabrol, T. Challan-Belval, Vanessa Chanteperdrix-Marillier, C. Chaplain, Caroline Charlier-Woerther, Hélène Chaussade, Catherine Chirouze, Bernard Clair, Julien Colot, Jean-Marie Conil, Hugues Cordel, Philippe Cormier, Joël Cousson, Pierrick Cronier, Eric Cua, Anne Dao-Dubremetz, S. Dargère, Nicolas Degand, S. Dekeyser, Déborah Delaune, Eric Denes, Pierre‐François Dequin, Diane Descamps, Elodie Descloux, Jean-Luc Desmaretz, Jean-Luc Diehl, Jérôme Dimet, Aurélien Dinh, Lelia Escaut, Claude Fabe, Frédéric Faibis, Clara Flateau, Nathalie Fonsale, E. Forestier, Nicolas Fortineau, Amandine Gagneux-Brunon, Caroline Garandeau, Magali Garcia, Denis Garot, Stéphane Gaudry, François Goehringer, Valérie Gregoire-Faucher, Marine Grosset, Camélia Gubavu, I. Gueït, D. Guélon, Thomas Guimard, Jérôme Guinard, Tahar Hadou, Jean-Pierre Helene, Sandrine Henard, Benoît Henry, Anne-Cécile Hochart, Bruno Hoen, Gabriela Illes, Sylvain Jaffuel, Irène Jarrin, Françoise Jaureguy, Cédric Joseph, Marie-Emmanuelle Juvin, Samer Kayal, Solen Kernéis, Lacassin, Isabelle Lamaury, Philippe Lanotte, E. Laurens, H. Laurichesse, Cécile Le Brun, Vincent Le Moing, Paul Le Turnier, Hervé Lecuyer, Sylvie Ledru, Céline Legrix, Adrien Lemaignen, Chantal Lemblé, Ludovic Lemée, Olivier Lesens, Marion Levast, Claire Lhommet, Silvija Males, Edith Malpote, Guillaume Martin‐Blondel, Matthieu Marx, Raphael Masson, Olivier Matray, Aurore Mbadi, F. Méchaï, Guillaume Mellon, Audrey Merens, M.C. Meyohas, Adrien Michon, Joy Mootien Yoganaden, David Morquin, Stéphane Mouly, Natacha Mrozek, Sophie Nguyen, Yohan N’Guyen, Maja Ogielska, Eric Oziol, Bernard Page, Solène Patrat-Delon, Isabelle Patry, André Pechinot, Stéphane Picot, Denys Pierrejean, Lionel Piroth, Claire Plassart, Patrice Plessis, L. Portel, P. Poubeau, Marie Poupard, Thiérry Prazuck, Luc Quaesaet, Adriatsiferana Ramanantsoa, Christophe Rapp, Laurent Raskine, Josette Raymond, Matthieu Revest, Agnès Riché, Stéphanie Robaday-Voisin, Frédéric Robin, Jean-Pierre Romaszko, Florence Rousseau, Anne‐Laure Roux, Cécile Royer, Matthieu Saada, Dominique Salmon, Carlo Saroufim, Jean Luc Schmit, Manuela Sébire, Christine Segonds, Valérie Sivadon‐Tardy, Nathalie Soismier, Olivia Son, Simon Sunder, Florence Suy, Didier Tandé, Jacques Tankovic, Nadia Valin, Nicolas Van Grunderbeeck, Emmanuelle Varon, Renaud Verdon, Michel Vergnaud, Véronique Vernet-Garnier, M. Vidal, Virginie Vitrat, Daniel Vittecoq, Fanny Vuotto, Isabelle Gorenne, Cédric Laouénan, Estelle Marcault, France Mentré, Blandine Pasquet, Carine Roy, Sarah Tubiana,

Sinusitis and nasal conditions

Little is known on headaches long-term persistence after bacterial meningitis and on their impact on patients' quality of life.In an ancillary study of the French national prospective cohort of community-acquired bacterial meningitis in adults (COMBAT) conducted between February 2013 and July 2015, we collected self-reported headaches before, at onset, and 12 months (M12) after meningitis. Determinants of persistent headache (PH) at M12, their association with M12 quality of life (SF 12), depression (Center for Epidemiologic Studies Depression Scale) and neuro-functional disability were analysed.Among the 277 alive patients at M12 87/274 (31.8%), 213/271 (78.6%) and 86/277 (31.0%) reported headaches before, at the onset, and at M12, respectively. In multivariate analysis, female sex (OR: 2.75 [1.54-4.90]; p < 0.001), pre-existing headaches before meningitis (OR: 2.38 [1.32-4.30]; p < 0.01), higher neutrophilic polynuclei percentage in the CSF of the initial lumbar puncture (OR: 1.02 [1.00-1.04]; p < 0.05), and brain abscess during the initial hospitalisation (OR: 8.32 [1.97-35.16]; p < 0.01) were associated with M12 persistent headaches. Neither the responsible microorganism, nor the corticoids use were associated with M12 persistent headaches. M12 neuro-functional disability (altered Glasgow Outcome Scale; p < 0.01), M12 physical handicap (altered modified Rankin score; p < 0.001), M12 depressive symptoms (p < 0.0001), and M12 altered physical (p < 0.05) and mental (p < 0.0001) qualities of life were associated with M12 headaches.Persistent headaches are frequent one year after meningitis and are associated with quality of life alteration.NCT01730690.