Design of experiment (DoE) as a quality by design (QbD) tool to optimise formulations of lipid nanoparticles for nose-to-brain drug delivery
2023; Taylor & Francis; Volume: 20; Issue: 12 Linguagem: Inglês
10.1080/17425247.2023.2274902
ISSN1744-7593
AutoresAline de Alcântara Correia, João Nuno Moreira, José Manuel Sousa Lobo, Ana Catarina Silva,
Tópico(s)Lipid Membrane Structure and Behavior
ResumoThe nose-to-brain route has been widely investigated to improve drug targeting to the central nervous system (CNS), where lipid nanoparticles (solid lipid nanoparticles - SLN and nanostructured lipid carriers - NLC) seem promising, although they should meet specific criteria of particle size (PS) <200 nm, polydispersity index (PDI) 80%. To optimize SLN and NLC formulations, design of experiment (DoE) has been recommended as a quality by design (QbD) tool.
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