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Blood-based Transcriptomic and Proteomic Biomarkers of Emphysema

2023; American Thoracic Society; Volume: 209; Issue: 3 Linguagem: Inglês

10.1164/rccm.202301-0067oc

1535-4970

Rahul Suryadevara, Andrew Gregory, Robin Lu, Zhonghui Xu, Aria Masoomi, Sharon M. Lutz, Seth Berman, Jeong H. Yun, Aabida Saferali, Min Hyung Ryu, Matthew Moll, Don D. Sin, Craig P. Hersh, Edwin K. Silverman, Jennifer Dy, Katherine Pratte, Russell P. Bowler, Peter J. Castaldi, Adel Boueiz, James D. Crapo, Edwin K. Silverman, Barry J. Make, Elizabeth A. Regan, Terri H. Beaty, Peter J. Castaldi, Michael H. Cho, Dawn L. DeMeo, Adel Boueiz, Marilyn G. Foreman, Auyon Ghosh, Lystra P. Hayden, Craig P. Hersh, Jacqueline B. Hetmanski, Brian D. Hobbs, John E. Hokanson, Wonji Kim, Nan M. Laird, Christoph Lange, Sharon M. Lutz, Merry‐Lynn McDonald, Dmitry Prokopenko, Matthew Moll, Jarrett D. Morrow, Dandi Qiao, Elizabeth A. Regan, Aabida Saferali, Phuwanat Sakornsakolpat, Edwin K. Silverman, Emily S. Wan, Jeong H. Yun, Juan Pablo Centeno, Jean‐Paul Charbonnier, Harvey O. Coxson, Craig J. Galbán, MeiLan K. Han, Eric A. Hoffman, Stephen M. Humphries, Francine L. Jacobson, Philip F. Judy, Ella A. Kazerooni, Alex Kluiber, David A. Lynch, Pietro Nardelli, John D. Newell, Aleena Notary, Andrea Oh, Elizabeth A. Regan, James C. Ross, Raúl San Jośe Estépar, Joyce Schroeder, Jered Sieren, Berend C. Stoel, Juerg Tschirren, Edwin J.R. van Beek, Bram van Ginneken, Eva M. van Rikxoort, Gonzalo Vegas Sanchez Ferrero, Lucas Veitel, George R. Washko, Carla G. Wilson, Robert T. Jensen, Douglas Curran‐Everett, Jim Crooks, Katherine Pratte, Matthew Strand, Carla G. Wilson, John E. Hokanson, Erin Austin, Gregory L. Kinney, Sharon M. Lutz, Kendra A. Young, Surya P. Bhatt, Jessica Bon, Alejandro A. Díaz, MeiLan K. Han, Barry J. Make, Susan Murray, Elizabeth A. Regan, Xavier Soler, Carla G. Wilson, Russell P. Bowler, Katerina Kechris, Farnoush Banaei Kashani, Jeffrey L. Curtis, Perry G. Pernicano, Nicola A. Hanania, Mustafa Atik, Aladin M. Boriek, Kalpatha Guntupalli, Elizabeth Guy, Amit Parulekar, Dawn L. DeMeo, Craig P. Hersh, Francine L. Jacobson, George R. Washko, R. Graham Barr, John Austin, Belinda D’Souza, Byron Thomashow, Neil MacIntyre, H. Page McAdams, Lacey Washington, Charlene McEvoy, Joseph Tashjian, Robert A. Wise, Robert Brown, Nadia N. Hansel, Karen M. Horton, Allison Lambert, Nirupama Putcha, Richard Casaburi, Alessandra Adami, Matthew J. Budoff, Hans Fischer, János Pórszász, Harry B. Rossiter, William W. Stringer, Amir Sharafkhaneh, Charlie Lan, Christine Wendt, Brian Bell, Ken M. Kunisaki, Eric L. Flenaugh, Hirut Gebrekristos, Mario Castro, Silanath Terpenning, Gloria Westney, Russell P. Bowler, David A. Lynch, Richard Rosiello, David Pace, Gerard J. Criner, David Ciccolella, Francis Cordova, Chandra Dass, Gilbert E. D’Alonzo, Parag Desai, Michael R. Jacobs, Steven G. Kelsen, Victor Kim, A.J. Mamary, Nathaniel Marchetti, Aditi Satti, Kartik Shenoy, Robert M. Steiner, Alex Swift, Irene Swift, Maria Elena Vega‐Sanchez, Mark T. Dransfield, William R. Bailey, Surya P. Bhatt, Anand Iyer, Hrudaya Nath, J. Michael Wells, Douglas Conrad, Xavier Soler, Andrew Yen, Alejandro P. Comellas, Karin F. Hoth, John D. Newell, Brad Thompson, MeiLan K. Han, Ella A. Kazerooni, Wassim W. Labaki, Craig J. Galbán, Dharshan Vummidi, Joanne Billings, Abbie Begnaud, Tadashi Allen, Frank C. Sciurba, Jessica Bon, Divay Chandra, Joel L. Weissfeld, Antonio Anzueto, Sylvia Adams, Diego Maselli-Caceres, Mario E. Ruiz, Harjinder Singh,

Respiratory Support and Mechanisms

Emphysema is a chronic obstructive pulmonary disease phenotype with important prognostic implications. Identifying blood-based biomarkers of emphysema will facilitate early diagnosis and development of targeted therapies.