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BIBTEX RIS

Predictors of early and long-term mortality after ICU discharge in critically ill COVID-19 patients: A prospective cohort study

2023; Public Library of Science; Volume: 18; Issue: 11 Linguagem: Inglês

10.1371/journal.pone.0293883

ISSN

1932-6203

Autores

Mariana Martins Siqueira Santos, Isabel Jesus Pereira, Nelson Cuboia, Joana Reis‐Pardal, Diana Adrião, Teresa Cardoso, Irene Aragão, Lurdes Santos, António Sarmento, Régis Goulart Rosa, Cristina Granja, Cassiano Teixeira, Luís Filipe Azevedo,

Tópico(s)

COVID-19 Clinical Research Studies

Resumo

To mitigate mortality among critically ill COVID-19 patients, both during their Intensive Care Unit (ICU) stay and following ICU discharge, it is crucial to measure its frequency, identify predictors and to establish an appropriate post-ICU follow-up strategy.In this multicentre, prospective cohort study, we included 586 critically ill COVID-19 patients.We observed an overall ICU mortality of 20.1% [95%CI: 17.1% to 23.6%] (118/586) and an overall hospital mortality of 25.4% [95%CI: 22.1% to 29.1%] (149/586). For ICU survivors, 30 days (early) post-ICU mortality was 5.3% [95%CI: 3.6% to 7.8%] (25/468) and one-year (late) post-ICU mortality was 7.9% [95%CI: 5.8% to 10.8%] (37/468). Pre-existing conditions/comorbidities were identified as the main independent predictors of mortality after ICU discharge: hypertension and heart failure were independent predictors of early mortality; and hypertension, chronic kidney disease, chronic obstructive pulmonary disease and cancer were independent predictors of late mortality.Early and late post-ICU mortality exhibited an initial surge (in the first 30 days post-ICU) followed by a subsequent decline over time. Close monitoring of critically ill COVID-19 post-ICU survivors, especially those with pre-existing conditions, is crucial to prevent adverse outcomes, reduce mortality and to establish an appropriate follow-up strategy.

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