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Radiotherapy to regional nodes in early breast cancer: an individual patient data meta-analysis of 14 324 women in 16 trials

2023; Elsevier BV; Volume: 402; Issue: 10416 Linguagem: Inglês

10.1016/s0140-6736(23)01082-6

1474-547X

Carolyn Taylor, David Dodwell, Paul McGale, Robert K. Hills, Richard Berry, Rosie Bradley, Jeremy Braybrooke, Mike Clarke, Richard Gray, Francesca Holt, Zulian Liu, Hongchao Pan, Richárd Pető, Ewan Straiton, Charlotte E. Coles, Fran Duane, Christophe Hennequin, Glenn Jones, Thorsten Kühn, Sileida Oliveros, Jens Overgaard, K.I. Pritchard, Chang‐Ok Suh, Graham Beake, Clare Boddington, Christina Davies, Lucy Davies, Vaughan Evans, Jo Gay, Lucy Gettins, Jon Godwin, Sam James, Amanda Kerr, Hui Liu, Elizabeth MacKinnon, Gurdeep Mannu, Theresa McHugh, Philip Morris, Mariko Nakahara, Simon Read, Hannah Taylor, John Ferguson, H Scheurlen, Stefano Zurrida, Viviana Galimberti, James N. Ingle, Pinuccia Valagussa, Umberto Veronesi, Stewart Anderson, Gong Tang, Bernard Fisher, Sophie D. Fosså, Kristin V. Reinertsen, Herman Høst, Hyman B. Muss, Kaija Holli, Kathy S. Albain, R. Arriagada, John M.S. Bartlett, Elizabeth Bergsten-Nordström, Judith M. Bliss, Étienne Brain, Lisa A. Carey, Robert E. Coleman, Jack Cuzick, Nancy E. Davidson, Lucia Del Mastro, Angelo Di Leo, James J. Dignam, Mitch Dowsett, Bent Ejlertsen, Prudence A. Francis, José Á. García-Sáenz, Rich Gelber, Michael Gnant, Matthew P. Goetz, Pam Goodwin, Pat Halpin-Murphy, Dan Hayes, Catherine Hill, Reshma Jagsi, Wolfgang Janni, Sibylle Loibl, Eleftherios P. Mamounas, Miguel Martín, Stuart McIntosh, Hirofumi Mukai, Valentina Nekljudova, Larry Norton, Yasuo Ohashi, Martine Piccart, Lori J. Pierce, Vinod Raina, Daniel Rea, Meredith M. Regan, J.F.R. Robertson, Emiel J. Rutgers, Roberto Salgado, Dennis J. Slamon, Tanja Španič, Joseph A. Sparano, Guenther G. Steger, Masakazu Toi, Andrew Tutt, Giuseppe Viale, Xiang Wang, Nicholas Wilcken, Norman Wolmark, Ke‐Da Yu, David Cameron, Jonas Bergh, Sandra M. Swain, Timothy J. Whelan, Philip Poortmans,

Cancer Cells and Metastasis

Radiotherapy has become much better targeted since the 1980s, improving both safety and efficacy. In breast cancer, radiotherapy to regional lymph nodes aims to reduce risks of recurrence and death. Its effects have been studied in randomised trials, some before the 1980s and some after. We aimed to assess the effects of regional node radiotherapy in these two eras.