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Phosphorothioate Oligonucleotides

1991; Oxford University Press; Linguagem: Inglês

10.1093/oso/9780199632800.003.0004

Gerald Zon, Wojciech J. Stec,

Synthesis and Characterization of Heterocyclic Compounds

Abstract Phosphorothioate analogues of DNA and RNA have sulphur in place of oxygen as one of the non-bridging ligands bonded to phosphorus. Differential electroncgativity, bond length, and other factors involving sulphur vs. oxygen lead to unique physicochcmical features for this class of backbone-modified analogues, relative to native DNA and RNA.