Portal de Periódicos da CAPES

Formulation and Evaluation of Herbal Cubepops

2023; Volume: 82; Issue: 2 Linguagem: Inglês

10.47583/ijpsrr.2023.v82i02.005

0976-044X

Prasuna Sundari Pingali, Sukesh Madhari, Sowmya Pujar, Gayathri Lingala, Bhargavi Bandi, Shivankitha Kattekola,

Natural Antidiabetic Agents Studies

Cold and cough are seasonal occurrences and sometimes quite frequent in individuals with low immunity and people with reported allergies.Though not serious, their symptoms pose discomfort, affect attendance, decrease concentration at work and, if not attended to, might lead to secondary infections.Herbs are time tested and therefore would be effective as an initial remedy.In the pharmaceutical market, herbal formulations for cough and cold are available as syrups, tablets, lozenges etc. Lozenges offer better patient compliance.Cube pops are available in the US market.Cube pops differ from lollipops in their shape, texture and chewability.The aim of the present study was to formulate and evaluate hard candy cube lollipops.Literature review indicated that myrobalan, tulsi, turmeric, ginger, vasaka, betel etc. as effective remedies.Dried juices and decoctions of herbs were prepared.Placebo cube pops were prepared for the selection of suitable excipients.Drug loaded cube pops F1, F2 and F3 were prepared and evaluated for shape, color, uniformity, texture, chewability, other formulation characteristics, and stability at room temperature.The results obtained are in compliance with the limits specified in IP.The antimicrobial activity of the prepared cube pops was determined against Staphylococcus aureus and Pseudomonas aeruginosa using the agar-well diffusion method.Vicks Cough Drops (lozenge) were taken as standard.The zone of inhibition obtained indicated that F3 formulated using herbal decoctions was better, as it exhibited 19 ± 0.3 and 17 ± 0.4 (in mm) against Staphylococcus aureus and Pseudomonas aeruginosa respectively.F3 was found to be stable when stored at 40°C.However, further studies need to be carried out to determine its stability and suitability across all temperature zones.