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TTF-1 status in early-stage lung adenocarcinoma is an independent predictor of relapse and survival superior to tumor grading

2023; Elsevier BV; Volume: 197; Linguagem: Inglês

10.1016/j.ejca.2023.113474

1879-0852

Simon Schallenberg, Gabriel Dernbach, Mihnea P. Dragomir, Georg Schlachtenberger, Kyrill Boschung, Corinna Friedrich, Kai Standvoss, Lukas Ruff, Philipp Anders, Christian Grohé, Winfried Randerath, Sabine Merkelbach‐Bruse, Alexander Quaas, Matthias Heldwein, Ulrich Keilholz, Jens Khosro Hekmat, Carsten Rückert, Reinhard Büttner, David Horst, Frederick Klauschen, Nikolaj Frost,

Lung Cancer Research Studies

Thyroid transcription factor 1 (TTF-1) is a well-established independent prognostic factor in lung adenocarcinoma (LUAD), irrespective of stage. This study aims to determine if TTF-1's prognostic impact is solely based on histomorphological differentiation (tumor grading) or if it independently relates to a biologically more aggressive phenotype. We analyzed a large bi-centric LUAD cohort to accurately assess TTF-1's prognostic value in relation to tumor grade.