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Genetic characterization of the ALFA study: Uncovering genetic profiles in the Alzheimer's continuum

2023; Wiley; Volume: 20; Issue: 3 Linguagem: Inglês

10.1002/alz.13537

1552-5279

Natàlia Vilor‐Tejedor, Patricia Genius, Blanca Rodríguez‐Fernández, Carolina Minguillón, Iman Sadeghi, Armand González‐Escalante, Marta Crous‐Bou, Marc Suárez‐Calvet, Oriol Grau‐Rivera, Anna Brugulat‐Serrat, Gonzalo Sánchez‐Benavides, Manel Esteller, Karine Fauria, José Luís Molinuevo, Arcadi Navarro, Juan Domingo Gispert,

Genetic Associations and Epidemiology

Abstract INTRODUCTION In 2013, the ALzheimer's and FAmilies (ALFA) project was established to investigate pathophysiological changes in preclinical Alzheimer's disease (AD), and to foster research on early detection and preventive interventions. METHODS We conducted a comprehensive genetic characterization of ALFA participants with respect to neurodegenerative/cerebrovascular diseases, AD biomarkers, brain endophenotypes, risk factors and aging biomarkers. We placed particular emphasis on amyloid/tau status and assessed gender differences. Multiple polygenic risk scores were computed to capture different aspects of genetic predisposition. We additionally compared AD risk in ALFA to that across the full disease spectrum from the Alzheimer's Disease Neuroimaging Initiative (ADNI). RESULTS Results show that the ALFA project has been successful at establishing a cohort of cognitively unimpaired individuals at high genetic predisposition of AD. DISCUSSION It is, therefore, well‐suited to study early pathophysiological changes in the preclinical AD continuum . Highlights Prevalence of ε4 carriers in ALzheimer and FAmilies (ALFA) is higher than in the general European population The ALFA study is highly enriched in Alzheimer's disease (AD) genetic risk factors beyond APOE AD genetic profiles in ALFA are similar to clinical groups along the continuum ALFA has succeeded in establishing a cohort of cognitively unimpaired individuals at high genetic AD risk ALFA is well suited to study pathogenic events/early pathophysiological changes in AD