Portal de Periódicos da CAPES

568: BMI AND CPK LEVELS IN COVID-19 PATIENTS: UNDERSTANDING THE LINK WITH ACUTE KIDNEY INJURY

2023; Lippincott Williams & Wilkins; Volume: 52; Issue: 1 Linguagem: Inglês

10.1097/01.ccm.0001000448.57707.5d

1530-0293

Jesus Mendez-Castro, Juan Manuel Méndez Castro, Mohamed Ziad-M. Said, LUZ M RAMIREZ, Paloma Molina, Ana Paula de Oliveira Villalobos, Jovana Texidor, Andrea Terrazas, Ana Cecilia Canto-Costal, René Figueroa, Joan Mathew, Isaac Aguilar, Joel Mongo, Daniel Patrón, Sammy Ghaou, JOSEPH VARON,

Acute Kidney Injury Research

Introduction: Acute Kidney Injury (AKI) contributes to the progress of coronavirus disease (COVID-19). However, its link with BMI and Creatinine Phosphokinase (CPK) is undetermined. We aim to investigate the relationship between AKI, BMI and CPK in patients admitted with COVID-19 infection. Methods: We retrospectively analyzed COVID-19 patients admitted from March 2020 to February 2022. BMI information was collected and the population divided into 6 groups: underweight, normal weight, overweight, obesity classes 1, 2 and 3. Primary outcome was AKI, and secondary CPK. IBM SPSS Statistics version 24.0 Descriptive statistics, U Mann-Withney and Kruskal Wallis with a Post-hoc analysis were used to analyze the data and its correlations. Results: The study included a total of 985 patients, 554(56.2%) were men and 431(43.8%) women, with a median age of 56 years[45-57] and a median BMI of 29.3 kg/m2[27-34.5 kg/m2]. 14 patients(1.4%) were underweight, 175(17.8%) with normal weight, 338(34.3%) overweight, 227(23%) obese class 1, 124(12.6%) obese class 2, and 107(10.9%) obese class 3. During the hospital stay, 78 (7.91%) patients developed AKI. Its distribution among the different BMI groups was as follows: 2(2.6%) underweight patients, 17(21.8%) normal weight patients, 20(25.6%) overweight, 16(20.5%) obese class 1, 10(12.8%) obese class 2, and 13(16.7%) obese class 3. We did not find a statistically significant association between BMI and AKI(p=0.28). A Mann-Withney U test was performed to evaluate if CPK level on admission differed by AKI. The results indicated that people with AKI had significantly greater CPK than people without it, p=< 0.001. The Kruskal Wallis analysis demonstrated a statistically significant correlation between BMI and CPK p=0.004. Bonferroni Post-hoc analysis shows significant association between obesity class 3 with higher CPK p=0.020. The medians of CPK in the different BMI groups were as follows: Underweight 46.5 mcg/L, Normal weight 81 mcg/L, Overweight 83 mcg/L, Obese class 1 84.5 mcg/L, Obese class 2 101.5 mcg/L, and Obese class 3 141 mcg/L. Conclusions: Our study found no significant association between BMI and AKI in critically ill COVID-19 patients. Higher CPK levels on admission correlated with the development of AKI and in patients with obesity class 3.