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De novo design of high-affinity binders of bioactive helical peptides

2023; Nature Portfolio; Volume: 626; Issue: 7998 Linguagem: Inglês

10.1038/s41586-023-06953-1

1476-4687

Susana Vázquez Torres, Philip J. Y. Leung, Preetham Venkatesh, Isaac D. Lutz, Fabian Hink, Huu‐Hien Huynh, Jessica O. Becker, Hsien‐Wei Yeh, David Juergens, Nathaniel R. Bennett, Andrew N. Hoofnagle, Eric Huang, Michael J. MacCoss, Marc Expòsit, Gyu Rie Lee, Asim K. Bera, Alex Kang, Joshmyn De La Cruz, Paul M. Levine, Xinting Li, Mila Lamb, Stacey Gerben, Analisa Murray, Piper Heine, Elif Nihal Korkmaz, Jeff Nivala, Lance Stewart, Joseph L. Watson, Joseph M. Rogers, David Baker,

Monoclonal and Polyclonal Antibodies Research

Many peptide hormones form an α-helix on binding their receptors