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Clinical characteristics and surgical outcomes of cardiac myxoma: A meta-analysis of worldwide experience

2023; Elsevier BV; Volume: 50; Issue: 2 Linguagem: Inglês

10.1016/j.ejso.2023.107940

1532-2157

Yudi Her Oktaviono, Pandit Bagus Tri Saputra, Jannatin Nisa Arnindita, Lelyana Sih Afgriyuspita, Roy Bagus Kurniawan, Diar Pasahari, Clonia Milla, Citrawati Dyah Kencono Wungu, Hendri Susilo, Chaq El Chaq Zamzam Multazam, Firas Farisi Alkaff,

Peptidase Inhibition and Analysis

Cardiac myxoma is the most common primary cardiac tumor. However, existing literature mainly consists of single-center experiences with limited subjects. This systematic review aimed to provide data on clinical characteristics and surgical outcomes of cardiac myxoma. We performed a thorough literature search on May 23, 2023 on PubMed, ProQuest, ScienceDirect, Scopus, and Web of Science. The inclusion criteria were English full-text, observational studies, and included >20 subjects. From the search, 112 studies with a total of 8150 patients were included in the analysis. The mean age was 51 years (95 % confidence interval [95%CI] = 49.1-52.3), and the majority were females (64.3 % [95 % CI = 62.8-65.8 %]). The most common clinical manifestation was cardiovascular symptoms. Echocardiography can diagnose almost all cases (98.1 % [95 % CI = 95.8-99.6 %]). Cardiac myxoma was mostly prevalent in left atrium (85.3 % [95%CI = 83.3-87 %]) and predominantly with pedunculated morphology (75.6 % [95%CI = 64.1-84.3 %]). Post-tumor excision outcomes were excellent, with an early mortality of 1.27 % (95 % CI = 0.8-1.8 %), late mortality rate of 4.7 (95 % CI = 2.5-7.4) per 1000 person-years, and recurrence rate at 0.5 (95 % CI = 0.0-1.1) per 1000 person-years. Tumor excision is warranted in a timely manner once the cardiac myxoma diagnosis is established.