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Variceal Bleeding in Children

2003; Lippincott Williams & Wilkins; Volume: 37; Issue: 5 Linguagem: Inglês

10.1002/j.1536-4801.2003.tb12058.x

1536-4801

Jean P. Molleston,

Gastrointestinal Bleeding Diagnosis and Treatment

Journal of Pediatric Gastroenterology and NutritionVolume 37, Issue 5 p. 538-545 Invited Review Variceal Bleeding in Children Jean Pappas Molleston, Corresponding Author Jean Pappas Molleston [email protected] Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Indianapolis, Indiana, U.S.A.Address correspondence and reprint requests to: Dr. Jean Pappas Molleston, Associate Professor of Clinical Pediatrics, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Division of Pediatric Gastroenterology, Hepatology and Nutrition, 702 Barnhill Drive, Room ROC 4210, Indianapolis, IN 46202 (e-mail: [email protected]).Search for more papers by this author Jean Pappas Molleston, Corresponding Author Jean Pappas Molleston [email protected] Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Division of Pediatric Gastroenterology, Hepatology and Nutrition, Indianapolis, Indiana, U.S.A.Address correspondence and reprint requests to: Dr. Jean Pappas Molleston, Associate Professor of Clinical Pediatrics, Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Division of Pediatric Gastroenterology, Hepatology and Nutrition, 702 Barnhill Drive, Room ROC 4210, Indianapolis, IN 46202 (e-mail: [email protected]).Search for more papers by this author First published: 01 November 2003 https://doi.org/10.1002/j.1536-4801.2003.tb12058.xCitations: 11Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1.Sharara AI, Rockey DC. Medical progress: gastroesophageal variceal hemorrhage. N Engl J Med 2001; 345: 669–81. 10.1056/NEJMra003007 CASPubMedWeb of Science®Google Scholar 2.Sokal EM, VanHoorebeeck N, VanObbergh L, et al. Upper gastro-intestinal tract bleeding in cirrhotic children candidates for liver transplantation. Eur J Pediatr 1992; 151: 326–8. 10.1007/BF02113249 CASPubMedWeb of Science®Google Scholar 3.Stringer MD, Howard ER, Mowat AP. Endoscopic sclerotherapy in the management of esophageal varices in 61 children with biliary atresia. J Pediatr Surg 1989; 24: 438–42. 10.1016/S0022-3468(89)80397-5 CASPubMedWeb of Science®Google Scholar 4.Miga D, Sokol RJ, MacKenzie T, et al. Survival after first esophageal variceal hemorrhage in patients with biliary atresia. J Pediatr 2001; 139: 291–6. 10.1067/mpd.2001.115967 CASPubMedWeb of Science®Google Scholar 5.Lykavieris P, Gauthier F, Hadchouel P, et al. Risk of gastrointestinal bleeding during adolescence and early adulthood in children with portal vein obstruction. J Pediatr 2000; 136: 805–8. 10.1016/S0022-3476(00)09680-3 CASPubMedWeb of Science®Google Scholar 6.Maksoud JG, Goncalves MEP, Porta G, et al. The endoscopic and surgical management of portal hypertension in children: analysis of 123 cases. J Pediatr Surg 1991; 26: 178–81. 10.1016/0022-3468(91)90904-8 CASPubMedWeb of Science®Google Scholar 7.Alvarez F, Bernard O, Brunelle F, et al. Portal obstruction in children: I. Clinical investigation and hemorrhage risk. J Pediatr 1983; 103: 696–702. 10.1016/S0022-3476(83)80460-0 CASPubMedWeb of Science®Google Scholar 8.Chalasani N, Kahi C, Francois F, et al. Improved patient survival after acute variceal bleeding: a multicenter, cohort study. Am J Gastroenterol 2003; 98: 653–9. 10.1111/j.1572-0241.2003.07294.x PubMedWeb of Science®Google Scholar 9.Howard ER, Stringer MD, Mowat AP. Assessment of injection sclerotherapy in the management of 152 children with oesophageal varices. Br J Surg 1988; 75: 404–8. 10.1002/bjs.1800750504 CASPubMedWeb of Science®Google Scholar 10.Yachha SK, Sharma BC, Kumar M, et al. Endoscopic sclerotherapy for esophageal varices in children with extrahepatic portal venous obstruction: a follow-up study. J Pediatr Gastroenterol Nutr 1997; 24: 49–52. 10.1097/00005176-199701000-00012 CASPubMedWeb of Science®Google Scholar 11.Sarin SK, Misra SP, Singal AK, et al. Endoscopic sclerotherapy for varices in children. J Pediatr Gastroenterol Nutr 1988; 7: 662–6. 10.1002/j.1536-4801.1988.tb09614.x CASPubMedWeb of Science®Google Scholar 12.Shah V. Cellular and molecular basis of portal hypertension. Clin Liver Dis 2001; 5: 629–45. 10.1016/S1089-3261(05)70185-9 CASPubMedGoogle Scholar 13. The North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study. The North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. N Engl J Med 1988; 319: 983–9. 10.1056/NEJM198810133191505 PubMedWeb of Science®Google Scholar 14.Fort E, Sautereau D, Silvain C, et al. A randomized trial of terlipressin plus nitroglycerin vs. balloon tamponade in the control of acute variceal hemorrhage. Hepatology 1990; 11: 678–81. 10.1002/hep.1840110423 CASPubMedWeb of Science®Google Scholar 15.Orloff MJ, Orloff MS, Girard B, et al. Bleeding esophagogastric varices from extrahepatic portal hypertension: 40 years' experience with portal-systemic shunt. J Am Coll Surg 2002; 194: 717–28. 10.1016/S1072-7515(02)01170-5 PubMedWeb of Science®Google Scholar 16.Merigan TC, Plotkin GR, Davidson CS. Effect of intravenously administered posterior pituitary extract on hemorrhage from bleeding esophageal varices. N Engl J Med 1962; 266: 134–5. 10.1056/NEJM196201182660307 PubMedWeb of Science®Google Scholar 17.Terblanche J, Bornman PC, Jonker MAT, et al. Injection sclerotherapy of esophageal varices. Semin Liver Dis 1982; 2: 233–41. 10.1055/s-2008-1040711 CASPubMedWeb of Science®Google Scholar 18.D'Amico G, Pietrosi G, Tarantino I, et al. Emergency sclerotherapy versus vasoactive drugs for variceal bleeding in cirrhosis: a Cochrane meta-analysis. Gastroenterology 2003; 124: 1277–91. 10.1016/S0016-5085(03)00269-5 CASPubMedWeb of Science®Google Scholar 19.Heikenen JB, Pohl JF, Werlin SL, et al. Octreotide in pediatric patients. J Pediatr Gastroenterol Nutr 2002; 35: 600–9. 10.1002/j.1536-4801.2002.tb07914.x CASPubMedWeb of Science®Google Scholar 20.Sarin SK, Kumar A. Sclerosants for variceal sclerotherapy: a critical appraisal. Am J Gastroenterol 1990; 85: 641–9. CASPubMedWeb of Science®Google Scholar 21.Laine L, Cook D. Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding: a meta-analysis. Ann Intern Med 1995; 123: 280–97. 10.7326/0003-4819-123-4-199508150-00007 CASPubMedWeb of Science®Google Scholar 22.Banares R, Albillos A, Rincon D, et al. Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis. Hepatology 2002; 35: 609–15. 10.1053/jhep.2002.31354 PubMedWeb of Science®Google Scholar 23.Fox VL, Carr-Locke DL, Connors PJ, et al. Endoscopic ligation of esophageal varices in children. J Pediatr Gastroenterol Nutr 1995; 20: 202–8. 10.1002/j.1536-4801.1995.tb11535.x CASPubMedWeb of Science®Google Scholar 24.McKiernan PJ, Beath SV, Davison SM. A prospective study of endoscopic esophageal variceal ligation using a multiband ligator. J Pediatr Gastroenterol Nutr 2002; 34: 207–11. 10.1002/j.1536-4801.2002.tb07602.x PubMedWeb of Science®Google Scholar 25.Zargar SA, Javid G, Khan BA, et al. Endoscopic ligation compared with sclerotherapy for bleeding esophageal varices in children with extrahepatic portal venous obstruction. Hepatology 2002; 36: 666–72. 10.1053/jhep.2002.35278 CASPubMedWeb of Science®Google Scholar 26.Tuggle DW, Bennett KG, Scott J, et al. Intravenous vasopressin and gastrointestinal hemorrhage in children. J Pediatr Surg 1988; 23: 627–9. 10.1016/S0022-3468(88)80631-6 CASPubMedWeb of Science®Google Scholar 27.Goenka AS, Dasilva MS, Cleghorn GJ, et al. Therapeutic upper gastrointestinal endoscopy in children: an audit of 443 procedures and literature review. J Gastroenterol Hepatol 1993; 8: 44–51. 10.1111/j.1440-1746.1993.tb01174.x CASPubMedWeb of Science®Google Scholar 28.Siafakas C, Fox VL, Nurko S. Use of octreotide for the treatment of severe gastrointestinal bleeding in children. J Pediatr Gastroenterol Nutr 1998; 26: 356–9. 10.1097/00005176-199803000-00022 CASPubMedWeb of Science®Google Scholar 29.Sasaki T, Hasegawa T, Nakajima K, et al. Endoscopic variceal ligation in the management of gastroesophageal varices in postoperative biliary atresia. J Pediatr Surg 1998; 33: 1628–32. 10.1016/S0022-3468(98)90595-4 CASPubMedWeb of Science®Google Scholar 30.Lam JC, Aters S, Tobias JD. Initial experience with octreotide in the pediatric population. Am J Ther 2001; 8: 409–15. 10.1097/00045391-200111000-00005 CASPubMedGoogle Scholar 31.Chalasani N, Imperiale T, Ismail A, et al. Predictors of large esophageal varices in patients with cirrhosis. Am J Gastroenterol 1999; 94: 3285–91. 10.1111/j.1572-0241.1999.1539_a.x CASPubMedWeb of Science®Google Scholar 32.Jensen DM. Endoscopic screening for varices in cirrhosis: findings, implications, and outcomes. Gastroenterology 2002; 122: 1620–30. 10.1053/gast.2002.33419 PubMedWeb of Science®Google Scholar 33.Grace ND. Diagnosis and treatment of gastrointestinal bleeding secondary to portal hypertension. Am J Gastroenterol 1997; 92: 1081–91. CASPubMedWeb of Science®Google Scholar 34.Grace ND, Groszmann RJ, Garcia-Tsao G, et al. Portal hypertension and variceal bleeding: an AASLD single topic symposium. Hepatology 1998; 28: 868–80. 10.1002/hep.510280339 CASPubMedGoogle Scholar 35.Spiegel BMR, Targownik L, Dulai GS, et al. Endoscopic screening for esophageal varices in cirrhosis: is it ever cost effective? Hepatology 2003; 37: 366–77. 10.1053/jhep.2003.50050 PubMedWeb of Science®Google Scholar 36.Feu F, Garcia-Pagan JC, Bosch J, et al. Relation between portal pressure response to pharmacotherapy and risk of recurrent variceal haemorrhage in patients with cirrhosis. Lancet 1995; 346: 1056–9. 10.1016/S0140-6736(95)91740-3 CASPubMedWeb of Science®Google Scholar 37.D'Amico G, Pagliaro L, Bosch J. The treatment of portal hypertension: a meta-analytic review. Hepatology 1995; 22: 332–54. 10.1002/hep.1840220145 PubMedWeb of Science®Google Scholar 38.Conn HO, Grace ND, Bosch J, et al. Propranolol in the prevention of the first hemorrhage from esophagogastric varices: a multicenter, randomized clinical trial. Hepatology 1991; 13: 902–12. 10.1002/hep.1840130517 CASPubMedWeb of Science®Google Scholar 39.Pagliaro L, D'Amico G, Sorensen TIA, et al. Prevention of first bleeding in cirrhosis. A meta-analysis of randomized trials of nonsurgical treatment. Ann Intern Med 1992; 117: 59–70. 10.7326/0003-4819-117-1-59 CASPubMedWeb of Science®Google Scholar 40.Abraczinskas DR, Ookubo R, Grace ND, et al. Propranolol for the prevention of first esophageal variceal hemorrhage: a lifetime commitment? Hepatology 2001; 34: 1096–102. 10.1053/jhep.2001.29305 CASPubMedWeb of Science®Google Scholar 41.Ozsoylu S, Kocak N, Yuce A. Propranolol therapy for portal hypertension in children. J Pediatr 1985; 106: 317–21. 10.1016/S0022-3476(85)80316-4 CASPubMedWeb of Science®Google Scholar 42.Shashidhar H, Langhans N, Grand RJ. Propranolol in prevention of portal hypertensive hemorrhage in children: a pilot study. J Pediatr Gastroenterol Nutr 1999; 29: 12–7. 10.1097/00005176-199907000-00007 CASPubMedWeb of Science®Google Scholar 43.Ozsoylu S, Kocak N, Demir H, et al. Propranolol for primary and secondary prophylaxis of variceal bleeding in children with cirrhosis. Turk J Pediatr 2000; 42: 31–3. CASPubMedWeb of Science®Google Scholar 44.Schreiber RA. Propranolol and portal hypertension: should kids be on the block? J Pediatr Gastroenterol Nutr 1999; 29: 10–1. 10.1097/00005176-199907000-00006 CASPubMedWeb of Science®Google Scholar 45.McKiernan PJ. Treatment of variceal bleeding. Gastrointest Endosc Clin North Am 2001; 11: 789–812. 10.1016/S1052-5157(18)30047-3 CASPubMedGoogle Scholar 46.Sarin SK, Lamba GS, Kumar M, et al. Comparison of endoscopic ligation and propranolol for the primary prevention of variceal bleeding. N Engl J Med 1999; 340: 988–93. 10.1056/NEJM199904013401302 CASPubMedWeb of Science®Google Scholar 47.Imperiale TF, Chalasani N. A meta-analysis of endoscopic variceal ligation for primary prophylaxis of esophageal variceal bleeding. Hepatology 2001; 33: 802–7. 10.1053/jhep.2001.23054 CASPubMedWeb of Science®Google Scholar 48.Lui HF, Stanley AJ, Forrest EH, et al. Primary prophylaxis of variceal hemorrhage: a randomized controlled trial comparing band ligation, propranolol, and isosorbide mononitrate. Gastroenterology 2002; 123: 735–44. 10.1053/gast.2002.35385 CASPubMedWeb of Science®Google Scholar 49.Paquet K-J. Ten years experience with paravariceal injection sclerotherapy of esophageal varices in children. J Pediatr Surg 1985; 20: 109–12. 10.1016/S0022-3468(85)80280-3 CASPubMedWeb of Science®Google Scholar 50.Goncalves MEP, Cardoso SR, Maksoud JG. Prophylactic sclerotherapy in children with esophageal varices: long-term results of a controlled prospective randomized trial. J Pediatr Surg 2000; 35: 401–5. 10.1016/S0022-3468(00)90203-3 CASPubMedWeb of Science®Google Scholar 51.Graham DY, Smith JL. The course of patients after variceal hemorrhage. Gastroenterology 1981; 80: 800–9. 10.1016/0016-5085(81)90144-X CASPubMedWeb of Science®Google Scholar 52.Bernard B, Lebrec D, Mathurin P, et al. Beta-adrenergic antagonists in the prevention of gastrointestinal rebleeding in patients with cirrhosis. A meta-analysis. Hepatology 1997; 25: 63–70. 10.1002/hep.510250112 CASPubMedWeb of Science®Google Scholar 53.Bernard B, Lebrec D, Mathurin P, et al. Propranolol and sclerotherapy in the prevention of gastrointestinal rebleeding in patients with cirrhosis: a meta-analysis. J Hepatol 1997; 26: 312–24. 10.1016/S0168-8278(97)80047-5 CASPubMedWeb of Science®Google Scholar 54.Villanueva C, Minana J, Ortiz J, et al. Endoscopic ligation compared with combined treatment with nadolol and isosorbide mononitrate to prevent recurrent variceal bleeding. N Engl J Med 2001; 345: 647–55. 10.1056/NEJMoa003223 CASPubMedWeb of Science®Google Scholar 55.Patch D, Sabin CA, Goulis J, et al. A randomized, controlled trial of medical therapy versus endoscopic ligation for the prevention of variceal rebleeding in patients with cirrhosis. Gastroenterology 2002; 123: 1013–9. 10.1053/gast.2002.35955 CASPubMedWeb of Science®Google Scholar 56.Lo G-H, Chen W-C, Chen M-H, et al. Banding ligation versus nadolol and isosorbide mononitrate for the prevention of esophageal variceal rebleeding. Gastroenterology 2002; 123: 728–34. 10.1053/gast.2002.35351 PubMedWeb of Science®Google Scholar 57.Lo G-H, Lai K-H, Cheng J-S, et al. Endoscopic variceal ligation plus nadolol and sucralfate compared with ligation alone for the prevention of variceal rebleeding: a prospective, randomized trial. Hepatology 2000; 32: 461–5. 10.1053/jhep.2000.16236 CASPubMedWeb of Science®Google Scholar 58.Price MR, Sartorelli KH, Karrer FM, et al. Management of esophageal varices in children by endoscopic variceal ligation. J Pediatr Surg 1996; 31: 1056–9. 10.1016/S0022-3468(96)90086-X CASPubMedWeb of Science®Google Scholar 59.Stringer MD, Howard ER. Longterm outcome after injection sclerotherapy for oesophageal varices in children with extrahepatic portal hypertension. Gut 1994; 35: 257–9. 10.1136/gut.35.2.257 CASPubMedWeb of Science®Google Scholar 60.Hill ID, Bowie MD. Endoscopic sclerotherapy for control of bleeding varices in children. Am J Gastroenterol 1991; 86: 472–6. CASPubMedWeb of Science®Google Scholar 61.Karrer FM, Holland RM, Allshouse MJ, et al. Portal vein thrombosis: treatment of variceal hemorrhage by endoscopic variceal ligation. J Pediatr Surg 1994; 29: 1149–51. 10.1016/0022-3468(94)90298-4 CASPubMedWeb of Science®Google Scholar 62.de Ville de Goyet J, Alberti D, Falchetti D, et al. Treatment of extrahepatic portal hypertension in children by mesenteric-to-left portal vein bypass: a new physiological procedure. Eur J Surg 1999; 165: 777–81. 10.1080/11024159950189573 PubMedGoogle Scholar 63.Bambini DA, Superina R, Almond PS, et al. Experience with the Rex shunt (mesenterico-left portal bypass) in children with extrahepatic portal hypertension. J Pediatr Surg 2000; 35: 13–9. 10.1016/S0022-3468(00)80005-6 CASPubMedWeb of Science®Google Scholar 64.Kamath PS, McKusick MA. Transvenous intrahepatic portosystemic shunts. Gastroenterology 1996; 111: 1700–5. 10.1016/S0016-5085(96)70035-5 CASPubMedWeb of Science®Google Scholar 65.Heyman MB, LaBerge JM, Somberg KA, et al. Transjugular intrahepatic portosystemic shunts (TIPS) in children. J Pediatr 1997; 131: 914–9. 10.1016/S0022-3476(97)70043-X CASPubMedWeb of Science®Google Scholar 66.Heyman MB, LaBerge JM. Role of transjugular intrahepatic portosystemic shunt in the treatment of portal hypertension in pediatric patients. J Pediatr Gastroenterol Nutr 1999; 29: 240–9. 10.1097/00005176-199909000-00004 CASPubMedWeb of Science®Google Scholar 67.Fitzgerald JF, Clark JH. Manual of Pediatric Gastroenterology. New York: Churchill Livingstone Inc., 1988. Google Scholar Citing Literature Volume37, Issue5November 2003Pages 538-545 ReferencesRelatedInformation