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On‐Patient Temporary Medical Record for Accurate, Time‐Sensitive Information at the Point of Care

2024; Wiley; Volume: 34; Issue: 16 Linguagem: Inglês

10.1002/adfm.202311821

1616-3028

Joe Collins, Jooli Han, Morteza Sarmadi, Stephanie Allison‐Logan, Aurélien vander Straeten, Collin F. Perkinson, Sarah Acolaste, Maria Kanelli, John L. Daristotle, Ari Karchin, Mitchell Henderson, Mache Cruz, Dolev Artzi, Shahad K. Alsaiari, Linzixuan Zhang, Lauren Levy, Lowell Wood, Lihong Jing, Kevin J. McHugh, Moungi G. Bawendi, Róbert Langer, Ana Jaklenec,

Advanced Drug Delivery Systems

Abstract Accurate medical recordkeeping is important for personal and public health. Conventional forms of on‐patient medical information, such as medical alert bracelets or finger‐markings, may compromise patient privacy because they are readily visible to other people. Here, the development of an invisible, temporary, and easily deployable on‐patient medical recordkeeping system is reported. Information is stored in unique patterns of spatially distributed near‐infrared (NIR) fluorescent quantum dots (QDs), which are delivered to the skin using dissolvable microneedle arrays. The patterns are invisible to the naked eye but detectable with an infrared camera, which can extract information with >98% accuracy using automated pattern recognition software. By encapsulating NIR QDs in an FDA‐approved biodegradable polymer, biodegradation rates can be tuned so that the encoded medical information can be conveyed in both a spatial and temporal manner, with some components fading within 100 days and others persisting for 6 months. This may be particularly useful for administering a series of vaccinations or treatments by indicating if enough time has passed for the patient to receive the next dose. Importantly, this system contains no personal information, does not require connection to a centralized database, and is not visible to the naked eye, ensuring patient privacy.