Association between altered tryptophan metabolism, plasma aryl hydrocarbon receptor agonists, and inflammatory Chagas disease
2024; Frontiers Media; Volume: 14; Linguagem: Inglês
10.3389/fimmu.2023.1267641
ISSN1664-3224
AutoresLaura Fernanda Ambrosio, Ximena Volpini, Juan Nahuel Quiróz, María Belén Brugo, Carolina P. Knubel, Melisa Rocío Herrera, Laura Fozzatti, Julián Avila Pacheco, Clary B. Clish, Maisa C. Takenaka, Juan Beloscar, Martín G. Theumer, Francisco J. Quintana, Ana Rosa Pérez, Claudia C. Motrán,
Tópico(s)Adenosine and Purinergic Signaling
ResumoChagas disease causes a cardiac illness characterized by immunoinflammatory reactions leading to myocardial fibrosis and remodeling. The development of Chronic Chagas Cardiomyopathy (CCC) in some patients while others remain asymptomatic is not fully understood, but dysregulated inflammatory responses are implicated. The Aryl hydrocarbon receptor (AhR) plays a crucial role in regulating inflammation. Certain tryptophan (Trp) metabolites have been identified as AhR ligands with regulatory functions.
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