Artigo Acesso aberto Revisado por pares

Immunohistochemical expression of vitamin d receptor (vdr) in urinary bladder squamous cell carcinoma

2024; Federation of Turkish Pathology Societies; Linguagem: Inglês

10.5146/tjpath.2023.12863

ISSN

1309-5730

Autores

Rehab Mohamed Sharaf, Passant Essam Eldin-Shibel, Nadia Ahmed Abd-El-Moeze,

Tópico(s)

Vitamin D Research Studies

Resumo

Squamous cell carcinoma (SCC) of the urinary bladder is associated with aggressive behavior and is typically treated with radical cystectomy. Vitamin D receptor (VDR) and its ligand Calcitriol have shown anti-tumor effects in various malignancies but to our knowledge there is no current information on VDR expression in bladder SCC. This study aimed to assess VDR immunostaining patterns in pure bladder SCC and its relation to the available clinicopathological parameters of such tumors.

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