Produção Nacional
Revisado por pares
The impact of obesity in hospitalized patients with COVID-19: a retrospective cohort study
2024; BioMed Central; Volume: 16; Issue: 1 Linguagem: Inglês
10.1186/s13098-023-01246-z
ISSN1758-5996
AutoresF Carrà, Maria Edna de Melo, Matheo Augusto Morandi Stumpf, Cíntia Cercato, Ariana E. Fernandes, Márcio C. Mancini, Adriana Sayuri Hirota, Alberto Kendy Kanasiro, Alessandra Crescenzi, Amanda Coelho Fernandes, Anna Miethke-Morais, Arthur Petrillo Bellintani, Artur Ribeiro Canasiro, Bárbara Vieira Carneiro, Beatriz Keiko Zanbon, Bernardo Pinheiro, Senna Nogueira Batista, Bianca Ruiz Nicolao, Bruno Adler Maccagnan Pinheiro Besen, Bruno Biselli, Bruno Rocha de Macedo, Caio Machado Gomes De Toledo, Carlos Roberto Ribeiro de Carvalho, Caroline Gomes Mól, Cassio Stipanich, Cauê Gasparotto Bueno, Cibele Larrosa Garzillo, Clarice Tanaka, Daniel Neves Forte, Daniel Joelsons, Daniele Robira, Eduardo Leite Vieira Costa, Elson Mendes Da Silva Júnior, Fabiane Aliotti Regalio, Gabriela Cardoso Segura, Giulia Sefrin Louro, Gustavo Brasil Marcelino, Chung-Chou H. Chang, Isabela Argollo Ferreira, Jeison Oliveira Gois, João Manoel Silva, José Otto Reusing, Julia Fray Ribeiro, Juliana Carvalho Ferreira, Karine Vusberg Galleti, Katia Regina da Silva, Larissa Padrão Isensee, Larissa Santos Oliveira, Leandro Utino Taniguchi, Leila Suemi Harima Letaif, Lígia Trombetta Lima, Lucas Yongsoo Park, Lucas Chaves Netto, Luciana Cassimiro Nobrega, Luciana Bertocco Paiva Haddad, Ludhmila Abrahão Hajjar, Luíz Marcelo Sá Malbouisson, Manuela Cristina Adsuara Pandolfi, Marcelo Park, Maria José Carvalho Carmona, Maria Castilho Prandini H De Andrade, Mariana Moreira Santos, Matheus Pereira Bateloche, Mayra Akimi Suiama, Mayron F. Oliveira, Mayson Laércio de Araújo Sousa, Michelle Louvaes Garcia, Natassja Huemer, Pedro Vitale Mendes, Paulo Ricardo Gessolo Lins, Pedro Gaspar Dos Santos, Pedro Ferreira Paiva Moreira, Renata Mello Guazzelli, Renato Batista Dos Reis, Renato Daltro-Oliveira, Roberta Muriel Longo Roepke, Rodolpho Augusto Moura Pedro, Rodrigo Kondo, Samia Zahi Rached, Sergio Roberto Silveira Da Fonseca, Thais Sousa Borges, Thalissa Ferreira, Vilson Cobello, Vivian Vieira Tenório Sales, Willaby Serafim Cassa Ferreira,
Tópico(s)Thermal Regulation in Medicine
ResumoAbstract Background Obesity is believed to be a risk factor for COVID-19 and unfavorable outcomes, although data on this remains to be better elucidated. Objective To evaluate the impact of obesity on the endpoints of patients hospitalized due to SARS-CoV-2. Methods This retrospective cohort study evaluated patients hospitalized at a tertiary hospital (Hospital das Clínicas da Faculdade de Medicina da USP) from March to December 2020. Only patients positive for COVID-19 (real-time PCR or serology) were included. Data were collected from medical records and included clinical and demographic information, weight and height, SAPS-3 score, comorbidities, and patient-centered outcomes (mortality, and need for mechanical ventilation, renal replacement therapy, or vasoactive drugs). Patients were divided into categories according to their BMI (underweight, eutrophic, overweight and obesity) for comparison porpoise. Results A total of 2547 patients were included. The mean age was 60.3 years, 56.2% were men, 65.2% were white and the mean BMI was 28.1 kg/m 2 . SAPS-3 score was a risk factor for all patient-centered outcomes (HR 1.032 for mortality, OR 1.03 for dialysis, OR 1.07 for vasoactive drug use, and OR 1.08 for intubation, p < 0.05). Male sex increased the risk of death (HR 1.175, p = 0.027) and dialysis (OR 1.64, p < 0.001), and underweight was protective for vasoactive drug use (OR 0.45, p = 0.027) and intubation (OR 0.31, p < 0.003). Conclusion Obesity itself was not an independent factor for worse patient-centered outcomes. Critical clinical state (indirectly evaluated by SAPS-3) appears to be the most important variable related to hard outcomes in patients infected with COVID-19.
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