CAR‑T cell therapy: A breakthrough in traditional cancer treatment strategies (Review)
2024; Spandidos Publishing; Volume: 29; Issue: 3 Linguagem: Inglês
10.3892/mmr.2024.13171
ISSN1791-3004
AutoresDahua Sun, Xiang Shi, Sanyan Li, Xiaohua Wang, Yang Xiao, Meiping Wan,
Tópico(s)Viral Infectious Diseases and Gene Expression in Insects
ResumoChimeric antigen receptor (CAR)‑T cell therapy is an innovative approach to immune cell therapy that works by modifying the T cells of a patient to express the CAR protein on their surface, and thus induce their recognition and destruction of cancer cells. CAR‑T cell therapy has shown some success in treating hematological tumors, but it still faces a number of challenges in the treatment of solid tumors, such as antigen selection, tolerability and safety. In response to these issues, studies continue to improve the design of CAR‑T cells in pursuit of improved therapeutic efficacy and safety. In the future, CAR‑T cell therapy is expected to become an important cancer treatment, and may provide new ideas and strategies for individualized immunotherapy. The present review provides a comprehensive overview of the principles, clinical applications, therapeutic efficacy and challenges of CAR‑T cell therapy.
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