Clinical and Genomic Characteristics of a Clinical Listeria Monocytogenes ST120 Isolate Recovered from a Pregnant Woman
2024; Dove Medical Press; Volume: Volume 17; Linguagem: Inglês
10.2147/idr.s446860
ISSN1178-6973
AutoresJingrui Zhang, Zengbin Liu, Zhirong Li, Caihong Xu, Hongbin Wang, Rugang Yang, Li Liu,
Tópico(s)Salmonella and Campylobacter epidemiology
ResumoBackground: Maternal–fetal listeriosis, caused by Listeria monocytogenes , is a rare but serious infection. Herein, we report the clinical and genomic characteristics of a clinical L. monocytogenes ST120 isolate recovered from a pregnant woman. Methods: The clinical symptoms and treatment in pregnant woman were described in detail. Whole genome sequencing (WGS) was performed on the L. monocytogenes isolate SJZ_LM001, and the genomic characterization of the isolate was deeply analyzed. Results: The clinical symptoms in pregnant women were mainly fever, and the placenta experienced severe inflammation. The pregnant woman was treated with ampicillin for effective anti-infective therapy. Genomic analysis showed that isolate SJZ_LM001 is sequence type (ST) 120, belong to clonal complex (CC)8 and lineage II of L. monocytogenes . Additionally, the isolates SJZ_LM001 harbored a novel plasmid pSJZ_LM001, which carried arsenical resistance genes ( arsACD and acr3 ), and cadmium resistance genes ( cadAC ). Drug susceptibility testing showed that the isolate SJZ-LM001 was susceptible to ampicillin, meropenem, penicillin, and cotrimoxazole. Conclusion: This is the first to identify a clinical case of infection in a pregnant woman caused by ST120 L. monocytogenes in China. These findings could benefit our understanding of the genomic characteristics of L. monocytogenes , and the pregnancy-related listeriosis and providing early diagnosis and effective targeted treatment. Keywords: Listeria monocytogenes , whole genome sequence, ST120, plasmid
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