Synthesis of some chalcones derivatives series and their antituberculosis activity
2024; International Union of Pure and Applied Chemistry; Volume: 96; Issue: 3 Linguagem: Inglês
10.1515/pac-2023-1127
ISSN1365-3075
AutoresNoviany Noviany, Hasnah Osman, Suriyati Mohamad, Sutopo Hadi, Heri Satria, Buhani Buhani,
Tópico(s)Fungal Plant Pathogen Control
ResumoAbstract Chalcone is an important biosynthetic precursor, due to the diverse pharmacological activities. The aim of this current study was to synthesize 14 new chalcone derivatives compounds by incorporating p -alkoxyacetophenones with substituted benzaldehydes. Two new series of chalcone derivatives have been synthesized using the alkylation and the base catalysed Claisen-Schmidt condensation. All the synthesized compounds were fully characterized by IR, 1D NMR ( 1 H and 13 C NMR) and 2D NMR (COSY, HMQC, HMBC) as well as mass spectrometry analysis. All the synthesized compounds were assayed in vitro for their antituberculosis activities against Mycobacterium tuberculosis strain. Among them, compounds ( E )-1-[4-(heptoxy)phenyl]-3-(2-hydroxy-5-bromophenyl)prop-2-en-1-one ( 5a ), ( E )-1-[4-(octyloxy)phenyl]-3-(2-hydroxy-5-bromophenyl)prop-2-en-1-one ( 5b ) and ( E )-1-[4-(decyloxy)phenyl]-3-(2-hydroxy-5-bromophenyl)prop-2-en-1-one ( 5d ) showed good activities with the lowest MIC value of 12.5 μg/mL.
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