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Global-PPS targets for antimicrobial stewardship in paediatric patients at hospitals in Sanandaj, Western Iran, compared with Southeast Asian and European hospitals

2024; Elsevier BV; Volume: 36; Linguagem: Inglês

10.1016/j.jgar.2024.01.011

2213-7173

Jafar Soltani, Shirin Behzadi, Ines Pauwels, Herman Goossens, Ann Versporten, Katia Verhamme, Lorenz Vanneste, Hilde Jansens, Déborah Konopnicki, Markus Hufnagel, Vineela Chadalavada, Valentijn A. Schweitzer, Mari Rose Aplasca De los Reyes, Jemelyn Garcia, Roberto Del Bo, Jesús Barrio, Janelle B. Morga, Joan Bonaobra, Darel Gresan Quisil, Estella Muñasquer, Zenaida M. Javier, Maria J. Ramos, Lilibeth G. Salvio, Alberto Vergara, Catherine T. Jison, Joan E. Cerrada, Michelle L. Macasero, John Marz Richmond B. Pabalinas, Isaac Mayo, Keshia Kate S. Toledo, Desteen Abegail M. Layora, Keith Bryan S. Valenzuela, Ma. Charmain M. Hufano, Anna Andrea S. Sabado, Susana Tizon, Ralph Ancieto, Julie S. Yago, Katrina M. Somera, Ludovico L. Jurao, Ma Kristina U. Torio, Ma Tarcela Gler, Gina de Guzman Betito, Lozel Villadore, Dan Micko F. Pedron, R. Nava, Anthony Ceraos, Myrna Mendoza, Raquel Victoria M Ecarma, Bóris Afonso Cruz, Elsa M. Espeleta, Liezel C. Afaga, Jennifer Espiritu, Marie Paz S. Callos, Jannsen Villasis, Ofelia T. Monzon, Jay Ron Padua, Kara Marie Venice P. Medrano, Agnes Yabut, M. Palomo, Teresita Cherie Araneta, Stephen Rae G. Fontanilla, M. Mendoza, M. P., Nomi Aparece, Expedito Yala, Vivinia Paez, Eduardo Tamayo, Karl Evans R. Henson, Katrina Rayos, Mona Clare Rellamas, Yuriko A rguil, Maria Luna Parreno, Mary Jane Dolores Ayson, Mahathir Chan, Pilar Retamar, Anna Riddell,

Emergency and Acute Care Studies

Point prevalence surveys (PPS) provide valuable data on patterns of hospital antimicrobial administration. To identify quality improvement indicators, we evaluated antimicrobial prescribing patterns in children and neonates admitted to three referral centers in Sanandaj, western Iran and compared these with South-East Asian and European paediatric benchmark data. The standardized Global-PPS was performed to assess antimicrobial use in South-East Asia, including Sanandaj and European hospitals in 2019. Out of 4118, 2915 and 443 paediatric patients enrolled in South-East Asian, European and Sanandaj hospitals, 2342 (56.9%), 833 (28.6%) and 332 (74.9%) respectively; received at least one antimicrobial in 2019. The most commonly administered antibiotics in neonates were ampicillin in South-East Asia (30.3%) and Sanandaj (41.5%, often in combination with cefotaxime (29.0%)) whereas amoxicillin in Europe (20.0%). In children, ceftriaxone was most commonly prescribed in Sanandaj (62.4%) and South-East Asia (20.5%) as opposed to amoxicillin (11.8%) in Europe. Twice as many Watch antibiotics (83.0%) were prescribed on paediatric wards in Sanandaj compared with European paediatric wards (41.1%). All antimicrobials in Sanandaj hospitals were prescribed empirically and prolonged surgical prophylaxis was common (75.5%). The high prevalence of antibiotic prescribing, high empirical therapies and poor outcomes for antibiotic quality indicators strongly suggest the urgent need for an antibiotic stewardship program in Sanandaj hospitals where improved diagnostic laboratory capacity and reconsideration of training may be good targets for intervention in our hospitals.