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Outcome of Epilepsy Surgery in MRI-Negative Patients Without Histopathologic Abnormalities in the Resected Tissue

2024; Lippincott Williams & Wilkins; Volume: 102; Issue: 4 Linguagem: Inglês

10.1212/wnl.0000000000208007

1526-632X

Maurits Sanders, Iskander Van der Wolf, Floor E. Jansen, Eleonora Aronica, Christoph Helmstaedter, Áttila Rácz, Rainer Surges, Alexander Grote, Albert J. Becker, Sylvain Rheims, Hélène Catenoix, John S. Duncan, Jane de Tisi, Thomas S. Jacques, J. Helen Cross, Reetta Kälviäinen, Tuomas Rauramaa, Francine Chassoux, Bertrand Devaux, Giancarlo Di Gennaro, Vincenzo Esposito, István Bódi, Mrinalini Honavar, Christian G. Bien, Thomas Cloppenborg, Roland Coras, Hajo M. Hamer, Petr Marusič, Adam Kalina, Tom Pieper, Manfred Kudernatsch, Till Hartlieb, Tim J. von Oertzen, Martin Aichholzer, Georg Dorfmüller, Mathilde Chipaux, Soheyl Noachtar, Elisabeth Kaufmann, Andreas Schulze‐Bonhage, Christian Scheiwe, Çiğdem Özkara, Thomas Grünwald, Kristina Koenig, Renzo Guerrini, Carmen Barba, Anna Maria Buccoliero, Flavio Giordano, Felix Rosenow, Katja Menzler, Rita Garbelli, Francesco Deleo, Pavel Kršek, Barbora Straka, Alexis Arzimanoglou, Joseph Toulouse, Wim Van Paesschen, Tom Theys, José Pimentel, Isabel Amorim, Nicola Specchio, Luca De Palma, Martha Feucht, Theresa O. Scholl, Karl Roessler, Rafael Toledano, António Gil‐Nagel, Savo Raičević, Aleksandar J. Ristić, Olaf Schijns, Jan Beckervordersandforth, Victoria San Antonio‐Arce, Jordi Rumià, Ingmar Blümcke, Kees P. J. Braun,

Neuroscience and Neuropharmacology Research

Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared with lesional patients. In this study, we aimed to characterize a large group of patients with focal epilepsy who underwent epilepsy surgery despite a normal MRI and had no lesion on histopathology. Determinants of their postoperative seizure outcomes were further studied.