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Antimicrobial Activity of Hydralazine Against Methicillin-Resistant and Methicillin-Susceptible Staphylococcus Aureus

2024; Future Medicine; Volume: 19; Issue: 2 Linguagem: Inglês

10.2217/fmb-2023-0160

1746-0921

Francisca Bruna Stefany Aires do Nascimento, Lívia Gurgel do Amaral Valente Sá, João Batista de Andrade Neto, Lisandra Juvêncio da Silva, Daniel Sampaio Rodrigues, Vitória Pessoa de Farias Cabral, Amanda Dias Barbosa, Lara Elloyse Almeida Moreira, Camille R Braga Vasconcelos, Bruno C. Cavalcanti, Maria Erivanda França Rios, Jacilene Silva, Emmanuel Silva Marinho, Hélcio Silva dos Santos, Jacó RL de Mesquita, Marina Duarte Pinto Lobo, Manoel Odorico de Moraes, Hélio Vitoriano Nobre Júnior, Cecília Rocha da Silva,

Cancer therapeutics and mechanisms

Background: Staphylococcus aureus is a human pathogen responsible for high mortality rates. The development of new antimicrobials is urgent. Materials & methods: The authors evaluated the activity of hydralazine along with its synergism with other drugs and action on biofilms. With regard to action mechanisms, the authors evaluated cell viability, DNA damage and molecular docking. Results: MIC and minimum bactericidal concentration values ranged from 128 to 2048 μg/ml. There was synergism with oxacillin (50%) and vancomycin (25%). Hydralazine reduced the viability of biofilms by 50%. After exposure to hydralazine 2× MIC, 58.78% of the cells were unviable, 62.07% were TUNEL positive and 27.03% presented damage in the comet assay (p < 0.05). Hydralazine showed affinity for DNA gyrase and TyrRS. Conclusion: Hydralazine is a potential antibacterial.