Type III-B CRISPR-Cas cascade of proteolytic cleavages
2024; American Association for the Advancement of Science; Volume: 383; Issue: 6682 Linguagem: Inglês
10.1126/science.adk0378
ISSN1095-9203
AutoresJurre A. Steens, Jack P. K. Bravo, Carl Raymund P. Salazar, Çağlar Yildiz, Afonso M. Amieiro, Stephan Köstlbacher, Stijn H. P. Prinsen, A. Andres, Constantinos Patinios, Andreas Bardis, Arjan Barendregt, Richard A. Scheltema, Thijs J. G. Ettema, John van der Oost, David W. Taylor, Raymond H.J. Staals,
Tópico(s)RNA and protein synthesis mechanisms
ResumoThe generation of cyclic oligoadenylates and subsequent allosteric activation of proteins that carry sensory domains is a distinctive feature of type III CRISPR-Cas systems. In this work, we characterize a set of associated genes of a type III-B system from
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