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ICTV Virus Taxonomy Profile: Filoviridae 2024

2024; Microbiology Society; Volume: 105; Issue: 2 Linguagem: Inglês

10.1099/jgv.0.001955

1465-2099

Nadine Biedenkopf, Alexander Bukreyev, Kartik Chandran, Nicholas Di Paola, Pierre Formenty, Anthony Griffiths, Adam J. Hume, Elke Mühlberger, Netesov Sv, Gustavo Palacios, Janusz T. Pawęska, Sophie J. Smither, Ayato Takada, Victoria Wahl‐Jensen, Jens H. Kuhn,

Viral gastroenteritis research and epidemiology

Filoviridae is a family of negative-sense RNA viruses with genomes of about 13.1–20.9 kb that infect fish, mammals and reptiles. The filovirid genome is a linear, non-segmented RNA with five canonical open reading frames (ORFs) that encode a nucleoprotein (NP), a polymerase cofactor (VP35), a glycoprotein (GP 1,2 ), a transcriptional activator (VP30) and a large protein (L) containing an RNA-directed RNA polymerase (RdRP) domain. All filovirid genomes encode additional proteins that vary among genera. Several filovirids (e.g., Ebola virus, Marburg virus) are pathogenic for humans and highly virulent. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Filoviridae , which is available at www.ictv.global/report/filoviridae .