A free-radical design featuring an intramolecular migration for a synthetically versatile alkyl–(hetero)arylation of simple olefins
2024; Royal Society of Chemistry; Volume: 15; Issue: 11 Linguagem: Inglês
10.1039/d3sc06476j
ISSN2041-6539
AutoresDylan J. Babcock, Andrew J. Wolfram, Jaxon L. Barney, Santino M. Servagno, Ayush Sharma, Eric D. Nacsa,
Tópico(s)Catalytic Cross-Coupling Reactions
ResumoA free-radical approach featuring an intramolecular aryl migration has significantly expanded the scope for the alkyl–(hetero)arylation of simple olefins. It was also leveraged as the key step in a new synthesis of a recently approved pharmaceutical.
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