Voltar
Revisão Acesso aberto Produção Nacional Revisado por pares
BIBTEX RIS

The Mutographs biorepository: A unique genomic resource to study cancer around the world

2024; Elsevier BV; Volume: 4; Issue: 3 Linguagem: Inglês

10.1016/j.xgen.2024.100500

ISSN

2666-979X

Autores

Sandra Pérdomo, Behnoush Abedi‐Ardekani, Ana Carolina de Carvalho, Aida Ferreiro-Iglesias, Valérie Gaborieau, Thomas Cattiaux, Hélène Renard, Priscilia Chopard, Christine Carreira, Andreea Spanu, Arash Nikmanesh, Ricardo Cortez Cardoso Penha, Samuel O. Antwi, Patrícia Ashton‐Prolla, Cristina Canova, Taned Chitapanarux, Riley Cox, María Paula Curado, José Carlos de Oliveira, Charles P. Dzamalala, Elenora Fabianova, Lorenzo Ferri, Rebecca C. Fitzgerald, Lenka Foretová, Steven Gallinger, Alisa M. Goldstein, Ivana Holcátová, Antonio Delgado‐Huertas, Vladimí­r Janout, Sonata Jarmalaite, Radka Kaneva, Luiz Paulo Kowalski, Tomislav Kuliš, Παγώνα Λάγιου, Jolanta Lissowska, Reza Malekzadeh, Dana Mateș, Valerie McCorrmack, Diana Menya, Sharayu Mhatre, Blandina T. Mmbaga, André de Moricz, Péter Nyírády, Miodrag Ognjanovic, Kyriaki Papadopoulou, Jerry Polesel, Mark P. Purdue, Ștefan Rașcu, Lidia Maria Rebolho Batista, Rui Manuel Reis, Luís Felipe Ribeiro Pinto, Paula A. Rodríguez‐Urrego, Surasak Sangkhathat, Suleeporn Sangrajrang, Tatsuhiro Shibata, E. O. Stakhovsky, Beata Świątkowska, Carlos Vaccaro, José Roberto Vasconcelos de Podestá, Naveen Vasudev, Marta Vilensky, Jonathan Yeung, Давид Заридзе, Kazem Zendehdel, Ghislaine Scélo, Estelle Chanudet, Jingwei Wang, Stephen Fitzgerald, Calli Latimer, Sarah Moody, Laura Humphreys, Ludmil B. Alexandrov, Michael R. Stratton, Paul Brennan,

Tópico(s)

Molecular Biology Techniques and Applications

Resumo

Large-scale biorepositories and databases are essential to generate equitable, effective, and sustainable advances in cancer prevention, early detection, cancer therapy, cancer care, and surveillance. The Mutographs project has created a large genomic dataset and biorepository of over 7,800 cancer cases from 30 countries across five continents with extensive demographic, lifestyle, environmental, and clinical information. Whole-genome sequencing is being finalized for over 4,000 cases, with the primary goal of understanding the causes of cancer at eight anatomic sites. Genomic, exposure, and clinical data will be publicly available through the International Cancer Genome Consortium Accelerating Research in Genomic Oncology platform. The Mutographs sample and metadata biorepository constitutes a legacy resource for new projects and collaborations aiming to increase our current research efforts in cancer genomic epidemiology globally.

Referência(s)