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Protective role of SARS-CoV-2 anti-S IgG against breakthrough infections among European healthcare workers during pre and post-Omicron surge—ORCHESTRA project

2024; Springer Science+Business Media; Volume: 52; Issue: 4 Linguagem: Inglês

10.1007/s15010-024-02189-x

1439-0973

Gianluca Spiteri, Marika D’Agostini, Mahsa Abedini, Giorgia Ditano, Giulia Collatuzzo, Paolo Boffetta, Luigi Vimercati, Emanuele Sansone, Giuseppe De Palma, Alberto Modenese, Fabriziomaria Gobba, Filippo Liviero, Angelo Moretto, Marco Dell’Omo, Tiziana Fiordi, Francesca Larese Filon, Marcella Mauro, Concepción Violán, Dana Mateș, Jana Bérešová, Maria Grazia Lourdes Monaco, Angela Carta, Giuseppe Verlato, Stefano Porru,

COVID-19 epidemiological studies

Anti SARS-CoV-2 vaccination initially showed high effectiveness in preventing COVID-19. However, after the surge of variants of concern, the effectiveness dropped. Several studies investigated if this was related to the decrease of the humoral response over time; however, this issue is still unclear. The aim of this study was to understand whether SARS-CoV-2 anti-S IgG levels can be used to predict breakthrough infection risk and define the timing for further booster doses administration.