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Treatment Response Prediction in Major Depressive Disorder Using Multimodal MRI and Clinical Data: Secondary Analysis of a Randomized Clinical Trial

2024; American Psychiatric Association; Volume: 181; Issue: 3 Linguagem: Inglês

10.1176/appi.ajp.20230206

1535-7228

Maarten G. Poirot, Henricus G. Ruhé, Henk J. M. M. Mutsaerts, Ivan I. Maximov, Inge Rasmus Groote, Atle Bjørnerud, Henk A. Marquering, Liesbeth Reneman, Matthan W.A. Caan,

Advanced Neuroimaging Techniques and Applications

Response to antidepressant treatment in major depressive disorder varies substantially between individuals, which lengthens the process of finding effective treatment. The authors sought to determine whether a multimodal machine learning approach could predict early sertraline response in patients with major depressive disorder. They assessed the predictive contribution of MR neuroimaging and clinical assessments at baseline and after 1 week of treatment.