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Inflammatory biomarkers for neurobehavioral dysregulation in former American football players: findings from the DIAGNOSE CTE Research Project

2024; BioMed Central; Volume: 21; Issue: 1 Linguagem: Inglês

10.1186/s12974-024-03034-6

1742-2094

Suzan van Amerongen, Surya Pulukuri, Fatima Tuz‐Zahra, Yorghos Tripodis, Jonathan D. Cherry, Charles Bernick, Yonas E. Geda, Jennifer V. Wethe, Douglas I. Katz, Michael L. Alosco, Charles H. Adler, Laura J. Balcer, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Daniel H. Daneshvar, Elizabeth A. Colasurdo, Jeffrey J. Iliff, Gail Li, Elaine R. Peskind, Martha E. Shenton, Eric M. Reiman, Jeffrey L. Cummings, Robert A. Stern, Kewei Chen, Hillary Protas, Eric M. Reiman, Yi Su, Connie Boker, Michael L. Alosco, Rhoda Au, Robert C. Cantu, Lindsay A. Farrer, Robert Helm, Douglas I. Katz, Neil W. Kowall, Jesse Mez, Gustavo Mercier, James Otis, Robert A. Stern, Jason Weller, Tahlia Bragg, Irene Simkin, Diana Trujillo‐Rodriguez, Suzan van Amerongen, Alondra Andino, Shannon E. Conneely, Courtney Diamond, Tessa Fagle, Olivia Haller, Tennyson Hunt, Nicole Gullotti, Bailey Kossow, Carrie Kugelmass, Megan Mariani, Brian Mayville, Kathleen McLaughlin, Mary Nanna, Marty DiPopolo, Taylor Platt, Surya Pulukuri, Fiona Rice, Madison Sestak, Irene Simkin, Michael D. McClean, Yorghos Tripodis, Douglas S. Annis, Christine E. Chaisson, Diane Dixon, Carolyn Finney, Kerrin Gallagher, Kaitlin Hartlage, Jun Lü, Brett Martin, EO Ojo, Joseph Palmisano, Brittany Pine, Janani Ramachandran, Zachary Baucom, Fatima Tuz‐Zahra, Eukyung Yhang, Sylvain Bouix, Jennifer Fitzsimmons, Alexander P. Lin, Inga K. Koerte, Ofer Pasternak, Martha E. Shenton, Hector Arciniega, Tashrif Billah, Elena M. Bonke, Katherine M. Breedlove, Holly Carrington, Eduardo Coello, Michael J. Coleman, Omar John, Leonard Jung, Huijun Liao, Maria Loy, Elizabeth Rizzoni, Vivian Schultz, Annelise Silva, Brynn Vessey, Tim L. T. Wiegand, Sarah J. Banks, Charles Bernick, Jason Miller, Aaron Ritter, Marwan N. Sabbagh, Raelynn de la Cruz, Jan Durant, Morgan Golceker, Nicolette Harmon, Jaeson Kaylegian, Rachelle Long, Christin Nance, Priscilla Sandoval, Miranda Staples, Robert Turner, Emma F. Clark, Kenneth Marek, Andrew Serrano, Charles H. Adler, David W. Dodick, Yonas E. Geda, Jennifer V. Wethe, Amy Duffy, Bryce W. Falk, Marci Howard, Michelle Montague, Thomas Osgood, Debra Babcock, Patrick S.F. Bellgowan, Laura J. Balcer, William Barr, Judith D. Goldberg, Binu Joseph, Ivan I. Kirov, Yvonne W. Lui, Charles R. Marmar, Thomas Wısnıewskı, Alhassan Al-Kharafi, Allan George, Lisena Hasanaj, Sammie Martin, Edward P. Riley, William Runge, Liliana Serrano, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Jeffrey L. Cummings, Jeffrey J. Iliff, Gail Li, Deidre Janssen, James S. Meabon, Elaine R. Peskind, Juan Piantino, Abigail G. Schindler, Ronald G. Thomas, Elizabeth A. Colasurdo, Jane B. Shofer, Daniel S. Marcus, Jenny Gurney, Richard M. Greenwald, Keith A. Johnson,

Traumatic Brain Injury and Neurovascular Disturbances

Traumatic encephalopathy syndrome (TES) is defined as the clinical manifestation of the neuropathological entity chronic traumatic encephalopathy (CTE). A core feature of TES is neurobehavioral dysregulation (NBD), a neuropsychiatric syndrome in repetitive head impact (RHI)-exposed individuals, characterized by a poor regulation of emotions/behavior. To discover biological correlates for NBD, we investigated the association between biomarkers of inflammation (interleukin (IL)-1β, IL-6, IL-8, IL-10, C-reactive protein (CRP), tumor necrosis factor (TNF)-α) in cerebrospinal fluid (CSF) and NBD symptoms in former American football players and unexposed individuals.