A model of human neural networks reveals NPTX2 pathology in ALS and FTLD
2024; Nature Portfolio; Volume: 626; Issue: 8001 Linguagem: Inglês
10.1038/s41586-024-07042-7
ISSN1476-4687
AutoresMarián Hruška-Plocháň, Vera I. Wiersma, A Betz, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva‐Maria Hock, Elena Tantardini, Florent Laferrière, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez‐Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dáša Bohačiaková, Puneet Sharma, Laura De Vos, Karl Frontzek, Adriano Aguzzi, Tammaryn Lashley, Mark D. Robinson, Theofanis Karayannis, Martin Mueller, Andreas Hierlemann, Magdalini Polymenidou,
Tópico(s)Prion Diseases and Protein Misfolding
ResumoHuman cellular models of neurodegeneration require reproducibility and longevity, which is necessary for simulating age-dependent diseases. Such systems are particularly needed for TDP-43 proteinopathies
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