Portal de Periódicos da CAPES

Intra-prostatic tumour evolution, steps in metastatic spread and histogenomic associations revealed by integration of multi-region whole-genome sequencing with histopathological features

2024; BioMed Central; Volume: 16; Issue: 1 Linguagem: Inglês

10.1186/s13073-024-01302-x

1756-994X

Srinivasa R. Rao, Clare Verrill, Lucia Cerundolo, Nasullah Khalid Alham, Zeynep Kaya, Miriam O’Hanlon, Alicia Hayes, Adam Lambert, Martha G. James, Iain D. C. Tullis, Jane Niederer, Shelagh Lovell, Altan Omer, Francisco J. Martínez–López, Tom Leslie, Francesca M. Buffa, Richard J. Bryant, Alastair Lamb, Borivoj Vojnovic, David C. Wedge, Ian G. Mills, Dan J. Woodcock, Ian Tomlinson, Freddie C. Hamdy,

Urologic and reproductive health conditions

Extension of prostate cancer beyond the primary site by local invasion or nodal metastasis is associated with poor prognosis. Despite significant research on tumour evolution in prostate cancer metastasis, the emergence and evolution of cancer clones at this early stage of expansion and spread are poorly understood. We aimed to delineate the routes of evolution and cancer spread within the prostate and to seminal vesicles and lymph nodes, linking these to histological features that are used in diagnostic risk stratification.