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CD19 CAR T-Cell Therapy in Autoimmune Disease — A Case Series with Follow-up

2024; Massachusetts Medical Society; Volume: 390; Issue: 8 Linguagem: Inglês

10.1056/nejmoa2308917

1533-4406

Fabian Müller, Jule Taubmann, Laura Bucci, Artur Wilhelm, Christina Bergmann, Simon Völkl, Michael Aigner, Tobias Rothe, Ioanna Minopoulou, Carlo Tur, Johannes Knitza, Soraya Kharboutli, Sascha Kretschmann, Ingrid Vášová, Silvia Spoerl, Hannah Reimann, Luis E. Muñoz, Roman G. Gerlach, Simon Schäfer, Ricardo Grieshaber‐Bouyer, Anne‐Sophie Korganow, Dominique Farge, Dimitrios Mougiakakos, Aline Bözec, Thomas Winkler, Gerhard Krönke, Andréas Mackensen, Georg Schett,

Cutaneous lymphoproliferative disorders research

Treatment for autoimmune diseases such as systemic lupus erythematosus (SLE), idiopathic inflammatory myositis, and systemic sclerosis often involves long-term immune suppression. Resetting aberrant autoimmunity in these diseases through deep depletion of B cells is a potential strategy for achieving sustained drug-free remission.