Investigating Novel Thiophene Carbaldehyde Based Thiazole Derivatives as Potential Hits for Diabetic Management: Synthesis, In Vitro and In Silico Approach
2024; Wiley; Volume: 9; Issue: 8 Linguagem: Inglês
10.1002/slct.202304601
ISSN2365-6549
AutoresNajeeb Ullah, Aftab Alam, Zainab Zainab, Ahmed A. Elhenawy, Saira Naz, Mohammad Shahidul Islam, Shujaat Ahmad, Syed Adnan Alı Shah, Manzoor Ahmad,
Tópico(s)Click Chemistry and Applications
ResumoAbstract This research work is based on synthesis of eleven novel thiazole derivatives (3 a‐k) of thiophene carbaldehyde. All the synthesized compounds were successfully synthesized, characterized by 1 H‐NMR and EI‐MS spectroscopic techniques and finally subjected for their in vitro α‐glucosidase inhibitory activity. Seven derivatives 3 i (IC 50 =10.21±1.84 μM) , 3 b (IC 50 =11.14±0.99 μM) , 3 f (IC 50 =13.21±2.76 μM) , 3 h (IC 50 =14.21±0.31 μM) , 3 k (IC 50 =15.21±1.02 μM) , 3 e (IC 50 =16.21±1.32 μM), and 3 c (IC 50 =18.21±1.89 μM), in the series displayed excellent inhibitory potential better than the standard acarbose. However, two compounds 3 g (IC 50 =33.21±1.99 μM) and 3 d (IC 50 =42.31±2.12 μM) showed significant activity while two compounds 3 j and 3 a were found less active with IC 50 values of 82.31±0.31 and 88.36±1.21 μM respectively. Additional research revealed that the compounds are not exhibiting any cytotoxic effects. The molecular docking study of these derivatives showed their good binding potential for α‐glucosidase active site with excellent interactions and docking scores.
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