Mechanisms of Hepatic Fibrosis
1998; Lippincott Williams & Wilkins; Volume: 27; Issue: 1 Linguagem: Inglês
10.1002/j.1536-4801.1998.tb01103.x
ISSN1536-4801
AutoresR. Christopher Benyon, Michael J.P. Arthur,
Tópico(s)Connective Tissue Growth Factor Research
ResumoJournal of Pediatric Gastroenterology and NutritionVolume 27, Issue 1 p. 75-85 Invited Review Mechanisms of Hepatic Fibrosis R. Christopher Benyon, Corresponding Author R. Christopher Benyon n/[email protected] University Medicine, Southampton General Hospital, Southampton, United KingdomAddress correspondence and reprint requests to Dr. R. C. Benyon, Non-Clinical Lecturer, University Medicine, Southampton General Hospital, Southampton, SO16 6YD U.K.Search for more papers by this authorMichael J. P. Arthur, Michael J. P. Arthur University Medicine, Southampton General Hospital, Southampton, United KingdomSearch for more papers by this author R. Christopher Benyon, Corresponding Author R. Christopher Benyon n/[email protected] University Medicine, Southampton General Hospital, Southampton, United KingdomAddress correspondence and reprint requests to Dr. R. C. Benyon, Non-Clinical Lecturer, University Medicine, Southampton General Hospital, Southampton, SO16 6YD U.K.Search for more papers by this authorMichael J. P. Arthur, Michael J. P. Arthur University Medicine, Southampton General Hospital, Southampton, United KingdomSearch for more papers by this author First published: 01 July 1998 https://doi.org/10.1002/j.1536-4801.1998.tb01103.x Submitted September 9, 1997 Read the full textAbout ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. REFERENCES 1Clark SA, Angus HB, Cook HB, Oxner RBG, George PM, Fraser R. Defenestration of the hepatic sinusoids as a cause of hyperlipoproteinaemia in alcoholics. Lancet 1988; 8622: 1225–7. 10.1016/S0140-6736(88)90813-6 Google Scholar 2Hahn EG, Wick G, Pencev D, Timpl R. Distribution of basement membrane proteins in normal and fibrotic human liver: Collagen type IV laminin and fibronectin. Gut 1980; 21: 63–71. 10.1136/gut.21.1.63 CASPubMedWeb of Science®Google Scholar 3Blomhoff R, Rasmussen M, Nilsson A, et al. Hepatic retinol metabolism: Distribution of retinoids, enzymes, and binding proteins in isolated rat liver cells. J Biol Chem 1985; 260: 13560–5. 10.1016/S0021-9258(17)38759-8 CASPubMedWeb of Science®Google Scholar 4Konomi H, Sano J, Nagai Y. Immunohistochemical localization of type I, III and IV (basement membrane) collagens in the liver. Acta Pathol Jpn 1981; 31: 972–8. Google Scholar 5Voss B, Rauterberg J, Allam S, et al. Distribution of collagen type I, type III and of two non-collagenous components of basement membrane in human liver. Pathol Res Pract 1980; 170: 50–60. 10.1016/S0344-0338(80)80155-5 CASPubMedWeb of Science®Google Scholar 6Schuppan D, Becker J, Boehm J, et al. Immunofluorescent localization of type V collagen as fibrillar component of interstitial connective tissue of human oral mucosa, artery and liver. Cell Tissue Res 1986; 243: 535–43. 10.1007/BF00218060 CASPubMedWeb of Science®Google Scholar 7Loreal O, Clement B, Schuppan D, Rescan PY, Rissel M, Guillouzo A. Distribution and cellular origin of collagen VI during development and in cirrhosis. Gastroenterology 1992; 102: 980–7. 10.1016/0016-5085(92)90186-3 CASPubMedWeb of Science®Google Scholar 8Milani S, Herbst H, Schuppan D, Surrenti C, Riecken EO, Stein H. Cellular localization of type I III and IV procollagen gene transcripts in normal and fibrotic human liver. Am J Pathol 1990; 137: 59–70. CASPubMedWeb of Science®Google Scholar 9Schuppan D. Structure of extracellular matrix in normal and fibrotic liver: Collagens and glycoproteins. Semin Liver Dis 1990; 10: 1–10. 10.1055/s-2008-1040452 CASPubMedWeb of Science®Google Scholar 10Clement B, Grimaud JA, Campion JP, Deugnier Y, Guillouzo A. Cell types involved in collagen and fibronectin production in normal and fibrotic human liver. Hepatology 1986; 6: 225–34. 10.1002/hep.1840060212 CASPubMedWeb of Science®Google Scholar 11Vigano S, Milani S, Schuppan D, et al. Distribution of a new extracellular matrix glycoprotein, undulin, in normal and pathologic human liver. Ital J Gastroenterol 1990; 22: 269 Google Scholar 12Martinez-Hernandez A. The hepatic extracellular matrix. I. Electron immunohistochemical studies in normal rat liver. Lab Invest 1984; 51: 57–69. CASPubMedWeb of Science®Google Scholar 13Griffiths MR, Ferrier R, Schuppan D, Burt AD. Collagen type VI: A component of the perisinusoidal extracellular matrix in human liver. In: E Wisse, DL Knook, RS McCuskey, eds. Cells of the Hepatic Sinusoid. Vol 3. Leiden, The Netherlands: The Kupffer Cell Foundation. 1990: 155–60. Google Scholar 14Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology 1988; 94: 1053–62. 10.1016/0016-5085(88)90566-5 CASPubMedGoogle Scholar 15Geerts A, Schuppan D, Lazeroms S, De-Zanger R, Wisse E. Collagen type I and III occur together in hybrid fibrils in the space of Disse of normal rat liver. Hepatology 1990; 12: 233–41. 10.1002/hep.1840120209 CASPubMedWeb of Science®Google Scholar 16Clement B, Loreal O, Rescan P-Y, et al. Cellular origin in the hepatic extracellular matrix. In: AM Gressner, G Ramadori eds. Molecular and Cell Biology of Liver Fibrogenesis. Dordrecht, The Netherlands: Kluwer Academic Publishers, 1992: 85–98. Google Scholar 17Maher JJ, McGuire RF. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo. J Clin Invest 1990; 86: 1641–8. 10.1172/JCI114886 CASPubMedWeb of Science®Google Scholar 18Irving MG, Roll FJ, Huang S, Bissell DM. Characterisation and culture of sinusoidal endothelium from normal rat liver, lipoprotein uptake and collagen phenotype. Gastroenterology 1984; 87: 1233–47. 10.1016/0016-5085(84)90188-4 CASPubMedWeb of Science®Google Scholar 19Jarnagin WR, Rockey DC, Koteliansky VE, Wang SS, Bissell DM. Expression of variant fibronectins in wound healing: Cellular sources and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J Cell Biol 1994; 127: 2037–48. 10.1083/jcb.127.6.2037 CASPubMedWeb of Science®Google Scholar 20Tsutsumi M, Takada A, Takase S, Ooshima A. Connective tissue components in cultured parenchymal and nonparenchymal cells of rat liver. Lab Invest 1988; 58: 88–92. CASPubMedWeb of Science®Google Scholar 21Knittel T, Armbrust T, Schwogler S, Schuppan D, Ramadori G. Distribution and cellular origin of undulin in rat liver. Lab Invest 1992; 67: 779–87. CASPubMedWeb of Science®Google Scholar 22Arenson DM, Friedman SL, Bissell DM. Formation of extracellular matrix in normal rat liver: Lipocytes as a major source of proteoglycan. Gastroenterology 1988; 95: 441–7. 10.1016/0016-5085(88)90502-1 CASPubMedWeb of Science®Google Scholar 23Clement B, Laurent M, Guguen-Guillouzo C, Lebeau G, Guillouzo A. Types I and IV procollagen gene expression in cultured rat hepatocytes. Coll Relat Res 1988; 8: 349–59. 10.1016/S0174-173X(88)80006-2 CASPubMedWeb of Science®Google Scholar 24Ramadori G, Rieder H, Knittel T, Dienes HP, Meyer zum Buschenfelde K-H. Fat storing cells (FSC) of rat liver synthesize and secrete fibronectin. J Hepatol 1987; 4: 190–7. 10.1016/S0168-8278(87)80079-X CASPubMedWeb of Science®Google Scholar 25Maher JJ, Bissell DM, Friedman SL, Roll FJ. Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer. J Clin Invest 1988; 82: 450–9. 10.1172/JCI113618 CASPubMedWeb of Science®Google Scholar 26McGee JO, Patrick RS. The role of perisinusoidal cells in hepatic fibrogenesis. An electron microscopic study of acute carbon tetrachloride liver injury. Lab Invest 1972; 26: 429–40. CASPubMedWeb of Science®Google Scholar 27Rojkind M, Giambrone M-A, Biempica L. Collagen types in normal and cirrhotic liver. Gastroenterology 1979; 76: 710–9. 10.1016/S0016-5085(79)80170-5 CASPubMedWeb of Science®Google Scholar 28Kent G, Gay S, Inouye T, Bahu R, Minick OT, Popper H. Vitamin A-containing lipocytes and formation of type III collagen in liver injury. Proc Natl Acad Sci USA 1976; 73: 3719–22. 10.1073/pnas.73.10.3719 CASPubMedWeb of Science®Google Scholar 29Minato Y, Hasumura Y, Takeuchi J. The role of fat-storing cells in Disse space fibrogenesis in alcoholic liver disease. Hepatology 1983; 3: 559–66. 10.1002/hep.1840030414 CASPubMedWeb of Science®Google Scholar 30Takahara T, Kojima T, Miyabayashi C, et al. Collagen production in fat-storing cells after carbon tetrachloride intoxication in the rat. Immunoelectron microscopic observation of type I, type III collagens, and prolyl hydroxylase. Lab Invest 1988; 59: 509–21. CASPubMedWeb of Science®Google Scholar 31Nakatsukasa H, Nagy P, Evarts RP, Hsia CC, Marsden E, Thorgeirsson SS. Cellular distribution of transforming growth factor-beta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. J Clin Invest 1990; 85: 1833–43. 10.1172/JCI114643 CASPubMedWeb of Science®Google Scholar 32Knittel T, Schuppan D, Meyer zum Buschenfelde K-H, et al. Differential expression of collagen types I, III and IV by fat-storing(Ito) cells in vitro. Gastroenterology 1992; 102: 1724–35. 10.1016/0016-5085(92)91736-N CASPubMedWeb of Science®Google Scholar 33Friedman SL, Roll FJ, Boyles J, Bissell DM. Hepatic lipocytes: The principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA 1985; 82: 8681–5. 10.1073/pnas.82.24.8681 CASPubMedWeb of Science®Google Scholar 34Weiner FR, Giambrone MA, Czaja MJ, et al. Ito-cell gene expression and collagen regulation. Hepatology 1990; 11: 111–7. 10.1002/hep.1840110119 CASPubMedWeb of Science®Google Scholar 35Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G. Isolated hepatic lipocytes and Kupffer cells from normal human liver: Morphological and functional characteristics in primary culture. Hepatology 1992; 15: 234–43. 10.1002/hep.1840150211 CASPubMedWeb of Science®Google Scholar 36Kawase T, Shiratori Y, Sugimoto T. Collagen production by rat liver fat storing cells in 1 degree culture. Exp Cell Biol 1986; 54: 183–92. CASPubMedWeb of Science®Google Scholar 37Schafer S, Zerbe O, Gressner AM. The synthesis of proteoglycans in fat-storing cells of rat liver. Hepatology(Baltimore) 1987; 7: 680–7. 10.1002/hep.1840070411 CASPubMedWeb of Science®Google Scholar 38Burt AD. Cellular and molecular aspects of hepatic fibrosis. J Pathol 1993; 170: 105–14. 10.1002/path.1711700203 CASPubMedWeb of Science®Google Scholar 39Burt AD, Griffiths MR, Schuppan D, Voss B, MacSween RN. Ultrastructural localization of extracellular matrix proteins in liver biopsies using ultracryomicrotomy and immuno-gold labelling. Histopathology 1990; 16: 53–8. 10.1111/j.1365-2559.1990.tb01060.x CASPubMedWeb of Science®Google Scholar 40Seyer JM, Huherson ET, Kang AH. Collagen polymorphism in normal and cirrhotic human liver. J Clin Invest 1977; 59: 241–8. 10.1172/JCI108634 CASPubMedWeb of Science®Google Scholar 41Van Eyken P, Sciot R, Desmet VJ. Expression of the novel extracellular matrix component tenascin in normal and diseased human liver: An immunohistochemical study. J Hepatol 1990; 11: 43–52. 10.1016/0168-8278(90)90270-2 CASPubMedWeb of Science®Google Scholar 42Gressner AM, Haarmann R. Hyaluronic acid synthesis and secretion by rat liver fat storing cells (perisinusoidal lipocytes) in culture. Biochem Biophys Res Commun 1988; 151: 222–9. 10.1016/0006-291X(88)90582-7 CASPubMedWeb of Science®Google Scholar 43Johnson SJ, Hines E, Burt AD. Macrophage and perisinusoidal cell kinetics in acute liver injury. J Pathol 1992; 166: 351–8. 10.1002/path.1711660406 CASPubMedWeb of Science®Google Scholar 44Johnson SJ, Hines JE, Burt AD. Immunolocalization of proliferating perisinusoidal cells in rat liver. Histochem J 1992; 24: 67–72. 10.1007/BF01082441 CASPubMedWeb of Science®Google Scholar 45Beno DWA, Espinal R, Edelstein BM, Davis BH. Administration of prostaglandin-E1 analog reduces rat hepatic and Ito cell collagen gene expression and collagen accumulation after bile duct ligation injury. Hepatology 1993; 17: 707–14. 10.1002/hep.1840170427 CASPubMedWeb of Science®Google Scholar 46Hines JE, Johnson SJ, Burt AD. In vivo responses of perisinusoidal cells (lipocytes) and macrophages to cholestatic liver injury. Am J Pathol 1993; 142: 511–8. CASPubMedWeb of Science®Google Scholar 47Rockey DC, Boyles JK, Gabbiani G, Friedman SL. Rat hepatic lipocytes express smooth muscle actin upon activation in vivo and in culture. J Submicrosc Cytol Pathol 1992; 24: 193–203. CASPubMedWeb of Science®Google Scholar 48Leo MA, Mak KM, Savolainen ER, Lieber CS. Isolation and culture of myofibroblasts from rat liver (42193). Proc Soc Exp Biol Med 1985; 180: 382–91. 10.3181/00379727-180-42193 CASPubMedWeb of Science®Google Scholar 49Shiratori Y, Ichida T, Geerts A, Wisse E. Modulation of collagen synthesis by fat-storing cells, isolated from C14- or vitamin A-treated rats. Dig Dis Sci 1987; 32: 1281–9. 10.1007/BF01296379 CASPubMedWeb of Science®Google Scholar 50Mak KM, Leo AM, Lieber CS. Alcoholic liver injury in baboons: Transformation of lipocytes to transitional cells. Gastroenterology 1984; 87: 188–200. 10.1016/0016-5085(84)90143-4 CASPubMedWeb of Science®Google Scholar 51Horn T, Junge J, Christoffersen P. Early alcoholic liver injury. Activation of lipocytes in acinar zone 3 and correlation to degree of collagen formation in Disse space. J Hepatol 1986; 3: 333–40. 10.1016/S0168-8278(86)80486-X CASPubMedWeb of Science®Google Scholar 52Senoo H, Hata R-I, Nagai Y, Wake K. Stellate cells(vitamin A-storing cells) are the primary site of collagen synthesis in non-parenchymal cells in the liver. Biomed Res 1984; 5: 451–8. 10.2220/biomedres.5.451 CASWeb of Science®Google Scholar 53Schonthal A, Herrlich P, Rahmsdorf HJ, Ponta H. Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters. Cell 1988; 54: 325–34. 10.1016/0092-8674(88)90195-X CASPubMedWeb of Science®Google Scholar 54Friedman SL, Roll FJ, Boyles J, Arenson DM, Bissell DM. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem 1989; 264: 10756–62. 10.1016/S0021-9258(18)81686-6 CASPubMedWeb of Science®Google Scholar 55Friedman SL. The cellular basis of hepatic fibrosis: Mechanisms and treatment strategies. N Engl J Med 1993; 328: 1828–35. 10.1056/NEJM199306243282508 CASPubMedWeb of Science®Google Scholar 56Gressner AM, Hoffmann C, Lahme B, Scheckel L. Hepatocyte-injury stimulates the mitogenic activation of cultured fat storing cells. In: E Wisse, K Wake, DL Knook, eds. Cells of the Hepatic Sinusoid. Vol 5. Leiden, The Netherlands: The Kupffer Cell Foundation. 1995: 380–2. Google Scholar 57Gressner AM, Lahme B, Diehl A, Brenzel A. Hepatocytes greatly enhance the mitogenic effect of insulin-like growth factor (IGF)-1 and IGF-2 on cultured perisinusoidal lipocytes via secretion of IGF-binding protein-1: Multiple potential ways of paracrine regulation of lipocyte activation (abstract). Hepatology 1992; 16: 183A 10.1002/hep.1840160523 Google Scholar 58Scharf JG, Ramadori G, Braulke T, Hartmann H. Synthesis of insulin-like growth factor binding proteins and of the acid-labile subunit in primary cultures of rat hepatocytes, of kupffer cells, and in cocultures: Regulation by insulin, insulin-like growth factor, and growth hormone. Hepatology 1996; 23: 818–27. 10.1002/hep.510230424 CASPubMedWeb of Science®Google Scholar 59Brenzel A, Weiner OH, Gressner AM. Stage-dependent expression of insulin-like growth factor (IGF)-I- and IGF-II-binding sites in rat liver fat storing cells (FSC) during in vitro transformation to myofibroblasts (MFB). In: E Wisse, K Wake, DL Knook, eds. Cells of the Hepatic Sinusoid. Vol 5. Leiden, The Netherlands: The Kupffer Cell Foundation. 1995: 386–9. Google Scholar 60Pinzani M, Gesukado L, Sabbah GM, Abboud HE. Effects of platelet derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat storing cells. J Clin Invest 1989; 84: 1786–93. 10.1172/JCI114363 CASPubMedWeb of Science®Google Scholar 61Wong L, Yamasaki G, Johnson RJ, Friedman SL. Induction of beta-platelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture. J Clin Invest 1994; 94: 1563–9. 10.1172/JCI117497 CASPubMedWeb of Science®Google Scholar 62Reider H, Ramadori G, Dienes HP, Meyer zum Buschenfelde K-H. Sinusoidal endothelial cells from guinea pig synthesize and secrete cellular fibronectin in vitro. Hepatology 1987; 7: 856–64. 10.1002/hep.1840070511 PubMedWeb of Science®Google Scholar 63Marra F, Choudhury GG, Pinzani M, Abboud HE. Regulation of platelet-derived growth factor secretion and gene expression in human liver fat-storing cells. Gastroenterology 1994; 107: 1110–7. 10.1016/0016-5085(94)90236-4 CASPubMedWeb of Science®Google Scholar 64Farrell DE, Hines JE, Walls AF, Kelly PJ, Bennett MK, Burt AD. Intrahepatic mast cells in chronic liver diseases. Hepatology 1995; 22: 1175–81. 10.1002/hep.1840220425 CASPubMedWeb of Science®Google Scholar 65Rioux KP, Sharkey KA, Wallace JL, Swain MG. Hepatic mucosal mast cell hyperplasia in rats with secondary biliary cirrhosis. Hepatology 1996; 23: 888–95. 10.1002/hep.510230433 CASPubMedWeb of Science®Google Scholar 66Levi-Schaffer F, Rubinchik E. Mast cell role in fibrotic diseases. Isr J Med Sci 1995; 31: 450–3. CASPubMedWeb of Science®Google Scholar 67Ramadori G, Kupffer cells and fibrogenesis. In: B Clement, A Guillouzo. Eds. Cellular and Molecular Aspects of Cirrhosis. Montrouge: Colloque INSERM/John Libbey Eurotext. 1992: 169–76. Google Scholar 68Winwood PJ, Arthur MJP. Kupffer cells: Their activation and role in animal models of liver injury and human liver disease. Semin Liver Dis 1993; 13: 50–9. 10.1055/s-2007-1007337 CASPubMedWeb of Science®Google Scholar 69Meyer DH, Bachem MG, Gressner AM. Modulation of hepatic lipocyte proteoglycan synthesis and proliferation by Kupffer cell-derived transforming growth factors type beta 1 and type alpha. Biochem Biophys Res Commun 1990; 171: 1122–9. 10.1016/0006-291X(90)90801-S CASPubMedWeb of Science®Google Scholar 70Castilla A, Prieto J, Fausto N. Transforming growth factors beta-1 and alpha in chronic liver disease: Effects of interferon therapy. N Engl J Med 1991; 324: 933–40. 10.1056/NEJM199104043241401 CASPubMedWeb of Science®Google Scholar 71Milani S, Schuppan D, Herbst H, Surrenti C. Expression of transforming growth factor beta, in normal and fibrotic human liver. In: A Gressner, G Ramadori, eds. Molecular and Cell Biology of Liver Fibrogenesis. Dordrecht, The Netherlands: Kluwer Academic Publishers. 1992: 254–62. Google Scholar 72Nakatsukasa H, Evarts RP, Hsia CC, Thorgeirsson SS. Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver. Lab Invest 1990; 63: 171–80. CASPubMedWeb of Science®Google Scholar 73Manthey CL, Allan JB, Ellingsworth LR, Wahl SM. In situ expression of transforming growth factor-beta in streptococcal cell wall-induced granulomatous inflammation and hepatic fibrosis. Growth Factors 1990; 4: 17–26. 10.3109/08977199009011006 CASPubMedWeb of Science®Google Scholar 74Czaja MJ, Weiner FR, Flanders KC, et al. In vitro and in vivo association of transforming growth factor beta-1 with hepatic fibrosis. J Cell Biol 1989; 108: 2477–82. 10.1083/jcb.108.6.2477 CASPubMedWeb of Science®Google Scholar 75Tsukamoto H, Horne W, Kamimura S, et al. Experimental liver cirrhosis induced by alcohol and iron. J Clin Invest 1995; 96: 620–30. 10.1172/JCI118077 CASPubMedWeb of Science®Google Scholar 76Milani S, herbst H, Schuppan D, Stein H, Surrenti C. Transforming growth factor-beta1 and beta2 are differentially expressed in fibrotic liver disease. Am J Pathol 1991; 139: 1221–9. CASPubMedWeb of Science®Google Scholar 77Bissell DM, Wang SS, Jarnagin WR, Roll FJ. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest 1995; 96: 447–55. 10.1172/JCI118055 CASPubMedWeb of Science®Google Scholar 78De Bleser PJ, Niki T, Rogiers V, Geerts A. Transforming growth factor-b gene expression in normal and fibrotic rat liver. J Hepatol 1997; 26: 886–93. 10.1016/S0168-8278(97)80257-7 CASPubMedWeb of Science®Google Scholar 79Johnson SJ, Hillan KJ, Hines JE, Ferrier K, Burt AD. Proliferation and phenotypic modulation of perisinusoidal (Ito) cells following acute liver injury: Temporal relationship with TGF-beta 1 expression. In: B Clement, A Guillouzo, eds. Cellular and Molecular Aspects of Cirrhosis. Montrouge, France: Colloques INSERM/John Libbey Eurotext. 1992: 219–22. Google Scholar 80Bachem MG, Meyer D, Melchior R, Sell K-M, Gressner AM. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. J Clin Invest 1992; 89: 19–27. 10.1172/JCI115561 CASPubMedGoogle Scholar 81Bachem MH, Sell KM, Melchior R, Kropf J, Eller T, Gressner AM. TNF-alpha and TGF beta-1 stimulate fibronectin synthesis and the transdifferentiation of fat storing cells in rat liver to myofibroblasts. Virchows Arch B Cell Pathol 1993; 63: 123–30. 10.1007/BF02899251 CASPubMedWeb of Science®Google Scholar 82Matsuda Y, Matsumoto K, Ichida T, Nakamura T. Hepatocyte growth factor suppresses the onset of liver cirrhosis and abrogates lethal hepatic dysfunction in rats. J Biochem 1995; 118: 643–9. 10.1093/oxfordjournals.jbchem.a124958 CASPubMedWeb of Science®Google Scholar 83Bachem MG, Riess U, Melchior R, Sell KM, Gressner AM. Transforming growth factors (TGF alpha and TGF beta 1) stimulate chondroitin sulfate and hyaluronate synthesis in cultured rat liver fat storing cells. FEBS Lett 1989; 257: 134–7. 10.1016/0014-5793(89)81804-6 CASPubMedWeb of Science®Google Scholar 84Edwards DR, Murphy G, Reynolds JJ, et al. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J 1987; 6: 1899–904. 10.1002/j.1460-2075.1987.tb02449.x CASPubMedWeb of Science®Google Scholar 85Overall CM, Wrana JL, Sudek J. Independent regulation of collagenase, 72kD progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem 1989; 264: 1860–9. 10.1016/S0021-9258(18)94267-5 CASPubMedWeb of Science®Google Scholar 86Friedman SL, Yamasaki G, Wong L. Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. J Biol Chem 1994; 269: 10551–8. 10.1016/S0021-9258(17)34095-4 CASPubMedWeb of Science®Google Scholar 87Border WA, Okuda S, Languino LR, Spom MB, Ruoslahti E. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature 1990; 346: 371–4. 10.1038/346371a0 CASPubMedWeb of Science®Google Scholar 88Border WA, Noble NA, Yamamoto T, et al. Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature 1992; 360: 361–4. 10.1038/360361a0 CASPubMedWeb of Science®Google Scholar 89Isaka Y, Brees DK, Ikegaya K, et al. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 1996; 2: 418–23. 10.1038/nm0496-418 CASPubMedWeb of Science®Google Scholar 90Sanderson N, Factor V, Nagy P, et al. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci USA 1995; 92: 2572–6. 10.1073/pnas.92.7.2572 CASPubMedWeb of Science®Google Scholar 91Shah M, Foreman DM, Ferguson MWJ. Control of scarring in adult wounds by neutralising antibody to transforming growth factor beta. Lancet 1992; 339: 213–4. 10.1016/0140-6736(92)90009-R CASPubMedWeb of Science®Google Scholar 92Kojima S, Rifkin DB. Mechanism of retinoid-induced activation of latent transforming growth factor beta in bovine endothelial cells. J Cell Physiol 1993; 155: 323–32. 10.1002/jcp.1041550213 CASPubMedWeb of Science®Google Scholar 93De Bleser PJ, Jannes P, van Buul-Offers SC, et al. Insulin-like growth factor-II/mannose 6-phosphate receptor is expressed on CC14-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-beta in cocultures with sinusoidal endothelial cells. Hepatology 1995; 21: 1429–37. CASPubMedWeb of Science®Google Scholar 94Leyland H, Gentry J, Arthur MJP, Benyon RC. The plasminogen activating system in hepatic stellate cells. Hepatology 1996; 24: 1172–8. 10.1002/hep.510240532 CASPubMedWeb of Science®Google Scholar 95Frazier K, Williams S, Kothapalli D, Klapper H, Grotendorst GR. Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol 1996; 107: 404–11. 10.1111/1523-1747.ep12363389 CASPubMedWeb of Science®Google Scholar 96Friedman SL, Wei SH, Blaner WS. Retinol release by activated rat hepatic lipocytes-regulation by Kupffer cell-conditioned medium and PDGF. Am J Physiol 1993; 264: G947–52. CASPubMedWeb of Science®Google Scholar 97Geerts A, Vrijsen R, Schelliack P, Wisse E. Retinol affects the phenotype and protein synthesis of fat storing cell derived myofibroblasts in vitro. In: E Wisse, DL Knook, K Decker, eds. Cells of the Hepatic Sinusoid. Vol 2. Rijswijk, The Netherlands: The Kupffer Cell Foundation. 1989: 20–4. Google Scholar 98Davis BH, Kramer RT, Davidson NO. Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor beta production. J Clin Invest 1990; 86: 2062–70. 10.1172/JCI114943 CASPubMedWeb of Science®Google Scholar 99Davis BH, Rapp UR, Davidson NO. Retinoic acid and transforming growth factor beta differentially inhibit platelet-derived-growth-factor-induced ito-cell activation. Biochem J 1991; 278: 43–7. 10.1042/bj2780043 CASPubMedWeb of Science®Google Scholar 100Pinzani M, Gentilini P, Abboud HE. Phenotypical modulation of live fat-storing cells by retinoids. Influence on unstimulated and growth factor-induced cell proliferation. J Hepatol 1992; 14: 211–20. 10.1016/0168-8278(92)90160-Q CASPubMedWeb of Science®Google Scholar 101Hendriks HFJ, Bosma A, Brouwer A. Fat-storing cells: Hyper- and hypovitaminosis A and the relationships with liver fibrosis. Semin Liver Dis 1993; 13: 72–80. 10.1055/s-2007-1007339 CASPubMedWeb of Science®Google Scholar 102Friedman SL, Yamasaki G, Wong L, Buck J. 14-hydroxy 4,14-retro-retinol (14-HRR)-A novel metabolite of retinol produced by activated rat lipocytes in vivo and in culture (abstract). Hepatology 1992; 16: 143A Web of Science®Google Scholar 103Buck J, Derguini F, Levi E, Nakanishi K, Hammerling U. Intracellular signaling by 14-hydroxy-4, 14-retro-retinol. Science 1991; 254: 1654–6. 10.1126/science.1749937 CASPubMedWeb of Science®Google Scholar 104Weiner FR, Blaner WS, Czaja MJ, Shah A, Geerts A. Ito cell expression of a nuclear retinoic acid receptor. Hepatology 1992; 15: 336–42. 10.1002/hep.1840150226 CASPubMedWeb of Science®Google Scholar 105Ohata M, Lin M, Tsukamoto H. Diminished retinoic acid signalling in hepatic stellate cells in cholestatic liver fibrosis. Am J Physiol 1997; 272: G589–96. CASPubMedWeb of Science®Google Scholar 106Bissell DM, Caron JM, Babiss LE, Friedman JM. Transcriptional regulation of the albumin gene in cultured rat hepatocytes. Role of basement-membrane matrix. Mol Biol Med 1990; 7: 187–97. CASPubMedWeb of Science®Google Scholar 107Bissell DM, Arenson DM, Maher JJ, Roll FJ. Support of cultured hepatocytes by a laminin-rich gel. J Clin Invest 1987; 79: 801–12. 10.1172/JCI112887 CASPubMedWeb of Science®Google Scholar 108McGuire RF, Bissell DM, Boyles J, Roll FJ. Role of extracellular matrix in regulating fenestrations of endothelial cells isolated from normal rat liver. Hepatology 1992; 15: 989–97. 10.1002/hep.1840150603 CASPubMedWeb of Science®Google Scholar 109Geerts A, Vrijsen R, Rauterberg J, Burt A, Schellinck P, Wisse E. In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion. J Hepatol 1989; 9: 59–68. 10.1016/0168-8278(89)90076-7 CASPubMedWeb of Science®Google Scholar 110Winwood PJ, Schuppan D, Iredale JP, Kawser CA, Docherty AJP, Arthur MJP. Kupffer cell-derived 95kDa type IV collagenase/gelatinase B: Characterisation and expression in cultured cells. Hepatology 1995; 22: 304–15. 10.1002/hep.1840220142 CASPubMedWeb of Science®Google Scholar 111Vyas SK, Leyland H, Gentry J, Arthur MJP. Transin(stromelysin) is expressed in early rat lipocyte primary culture. Gastroenterology 1995; 109: 889–98. 10.1016/0016-5085(95)90399-2 CASPubMedWeb of Science®Google Scholar 112Arthur MJP, Friedman SL, Roll FJ, Bissell DM. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J Clin Invest 1989; 84: 1076–85. 10.1172/JCI114270 CASPubMedWeb of Science®Google Scholar 113Arthur MJP, Stanley A, Iredale JP, Rafferty JA, Hembry RM, Friedman SL. Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes: Analysis of gene expression, protein synthesis and proteinase activity. Biochem J 1992; 287: 701–7. 10.1042/bj2870701 CASPubMedWeb of Science®Google Scholar 114Khan NA, Soweid AM, O'Neill R, Li L, Britton RS, Brown KE. Reversal of activated lipocyte phenotype by culture on basement membrane-like extracellular matrix (abstract). Hepatology 1995; 26: 282A 10.1016/0270-9139(95)94852-X Google Scholar 115Ruoslahti E. Integrins. J Clin Invest 1991; 87: 1–5. 10.1172/JCI114957 CASPubMedWeb of Science®Google Scholar 116Volpes R, Van Den Oord JJ, Desmet VJ. Distribution of the VLA family of integrins in normal and pathological human liver tissue. Gastroenterology 1991; 101: 200–6. 10.1016/0016-5085(91)90478-4 CASPubMedWeb of Science®Google Scholar 117Hillis GS, MacLeod AM. Integrins and disease. Clin Sci 1996; 91: 639–50. 10.1042/cs0910639 CASPubMedWeb of Science®Google Scholar 118Lafrenie RM, Yamada KM. Integrin-dependent signal transduction. J Cell Biochem 1996; 61: 543–53. 10.1002/(SICI)1097-4644(19960616)61:4 3.0.CO;2-O CASPubMedWeb of Science®Google Scholar 119Carloni V, Romanelli RG, Pinzani M, Laffi G, Gentilini P. Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells. Gastroenterology 1996; 110: 1127–36. 10.1053/gast.1996.v110.pm8613002 CASPubMedWeb of Science®Google Scholar 120Reeves HL, Dack CL, Day CP, Burt AD. b1 integrin expression in hepatic stellate cells from normal and diseased human livers. In: E Wisse, DL Knook, C Balabaud, eds. Cells of the Hepatic Sinusoid. Vol 6. Leiden, The Netherlands: The Kupffer Cell Foundation. 1997: 154–5. Google Scholar 121Matrisian LM. The matrix-degrading metalloproteinases. Bioessays 1992; 14: 455–63. 10.1002/bies.950140705 CASPubMedWeb of Science®Google Scholar 122Denhardt DT, Feng B, Edwards DR, Cocuzzi ET, Malyankar UM. Tissue inhibitor of metalloproteinases (TIMP, aka EPA)-structure, control of expression and biological functions. Pharmacol Ther 1993; 59: 329–41. 10.1016/0163-7258(93)90074-N CASPubMedWeb of Science®Google Scholar 123Perez-Tamayo R, Montfort I, Gonzalez E. Collagenolytic activity in experimental cirrhosis of the liver. Exp Mol Pathol 1987; 47: 300–8. 10.1016/0014-4800(87)90015-3 CASPubMedWeb of Science®Google Scholar 124Okazaki I, Maruyama K. Collagenase activity in experimental hepatic fibrosis. Nature 1974; 252: 49–50. 10.1038/252049a0 CASPubMedWeb of Science®Google Scholar 125Maruyama K, Feinman L, Fainsilber Z, Nakano M, Okazaki I, Lieber CS. Mammalian collagenase increases in early alcoholic liver disease and decreases with cirrhosis. Life Sci 1982; 30: 1379–84. 10.1016/0024-3205(82)90023-6 CASPubMedWeb of Science®Google Scholar 126Montfort I, Perez-Tamayo R. Collagenase in experimental carbon tetrachloride cirrhosis of the liver. Am J Pathol 1978; 92: 411–20. CASPubMedWeb of Science®Google Scholar 127Takahashi S, Dunn MA, Seifter S. Liver collagenase in murine schistosomiasis. Gastroenterology 1980; 78: 1425–31. 10.1016/S0016-5085(19)30495-0 CASPubMedWeb of Science®Google Scholar 128Iredale JP, Goddard S, Murphy G, Benyon RC, Arthur MJP. Tissue inhibitor of metalloproteinase-1 and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes. Clin Sci 1995; 89: 75–81. 10.1042/cs0890075 CASPubMedWeb of Science®Google Scholar 129Benyon RC, Iredale JP, Goddard S, Winwood PJ, Arthur MJP. Expression of tissue inhibitor of metalloproteinases-1 and -2 in increased in fibrotic human liver. Gastroenterology 1996; 110: 821–31. 10.1053/gast.1996.v110.pm8608892 CASPubMedWeb of Science®Google Scholar 130Iredale JP, Murphy G, Hembry RM, Friedman SL, Arthur MJP. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1 (TIMP-1): Implications for regulation of matrix degradation in liver. J Clin Invest 1992; 90: 282–7. 10.1172/JCI115850 CASPubMedWeb of Science®Google Scholar 131Iredale JP, Benyon RC, Arthur MJP, et al. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Hepatology 1996; 24: 176–84. 10.1002/hep.510240129 CASPubMedWeb of Science®Google Scholar 132Iredale JP, Benyon RC, Ferris WF, et al. Tissue inhibitor of metalloproteinase-1 expression is up-regulated relative to interstitial collagenase in CC14 induced liver fibrosis and activated human hepatic lipocytes. In: E Wisse, K Wake, DL Knook, eds. Cells of the Hepatic Sinusoid. Vol 5. Leiden, The Netherlands: The Kupffer Cell Foundation. 1995; 419–20. Google Scholar 133Iredale JP, Pawley S, Hovell C, Pickering J, Arthur MJP, Benyon RC. Spontaneous recovery from fibrosis: Role of tissue inhibitors of metalloproteinases (TIMPs). (abstract) J Hepatol 1997; 26: 131 PubMedWeb of Science®Google Scholar 134Milani S, Herbst H, Schuppan D, et al. Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol 1994; 144: 528–37. CASPubMedWeb of Science®Google Scholar 135Theret N, Musso O, Lhelgoualch A, Clement B. Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes. Am J Pathol 1997; 150: 51–8. CASPubMedWeb of Science®Google Scholar 136Hovell CJ, Benyon RC, Baker JE, Arthur MJP. Membrane-type matrix metalloproteinase is produced by hepatic stellate cells(abstract). Hepatology 1995; 22(suppl): 369A. PubMedGoogle Scholar 137Benyon RC, Hovell CJ, Arthur MJP. Gelatinase A(72kDa type IV collagenase) is an autocrine proliferation factor for rat hepatic stellate cells (abstract). Hepatology 1997; 26: 186A PubMedWeb of Science®Google Scholar 138Turck J, Pollock AS, Lee LK, Marti H-P, Lovett DH. Matrix metalloproteinase 2 (gelatinase A) regulates glomerular mesangial cell proliferation and differentiation. J Biol Chem 1996; 271: 15074–83. 10.1074/jbc.271.25.15074 CASPubMedWeb of Science®Google Scholar 139Knittel T, Fellmer P, Ramadori G. Gene expression and regulation of plasminogen activator inhibitor type I in hepatic stellate cells of rat liver. Gastroenterology 1996; 111: 745–54. 10.1053/gast.1996.v111.pm8780581 CASPubMedWeb of Science®Google Scholar 140Mcgeehan GM, Becherer JD, Bast RC, et al. Regulation of tumour necrosis factor-alpha processing by a metalloproteinase inhibitor. Nature 1994; 370: 558–61. 10.1038/370558a0 CASPubMedWeb of Science®Google Scholar Volume27, Issue1July 1998Pages 75-85 ReferencesRelatedInformation
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