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Genome-wide association studies and Mendelian randomization analyses provide insights into the causes of early-onset colorectal cancer

2024; Elsevier BV; Volume: 35; Issue: 6 Linguagem: Inglês

10.1016/j.annonc.2024.02.008

1569-8041

Ruhina Shirin Laskar, Conghui Qu, Jeroen R. Huyghe, Tabitha A. Harrison, Richard B. Hayes, Yin Cao, Peter T. Campbell, Robert S. Steinfelder, Fazlur Rahman Talukdar, Hermann Brenner, Shuji Ogino, S. Brendt, D. Timothy Bishop, Daniel D. Buchanan, Andrew T. Chan, Michelle Cotterchio, Stephen B. Gruber, Andrea Gsur, Bethany Van Guelpen, Mark A. Jenkins, Temitope O. Keku, Brigid M. Lynch, Loı̈c Le Marchand, Richard M. Martin, Kathryn McCarthy, Vı́ctor Moreno, Rachel Pearlman, Mingyang Song, Konstantinos K. Tsilidis, Pavel Vodička, Michael O. Woods, Kana Wu, Li Hsu, Marc J. Gunter, Ulrike Peters, Neil Murphy,

Helicobacter pylori-related gastroenterology studies

The incidence of early-onset colorectal cancer (EOCRC; diagnosed <50 years of age) is rising globally; however, the causes underlying this trend are largely unknown. CRC has strong genetic and environmental determinants, yet common genetic variants and causal modifiable risk factors underlying EOCRC are unknown. We conducted the first EOCRC-specific genome-wide association study (GWAS) and Mendelian randomization (MR) analyses to explore germline genetic and causal modifiable risk factors associated with EOCRC.