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Specific Mutations Identified in Patients Vaccinated and Infected with COVID-19 in Senegal

2024; European Society of Medicine; Volume: 12; Issue: 2 Linguagem: Inglês

10.18103/mra.v12i2.4956

2375-1924

Abdou Padane, Djibril Wade, Cyrille K. Diédhiou, Marièma Sarr, Seyni Ndiaye, Abdoulaye Souaré, Mame Matar Diop, Khadim Gueye, Marilyne Aza-Gnandji, Ndéye Diabou Diagne, Nafissatou Lèye, Ndèye Dieynaba Diouf, Mame Ndiaye, Ndèye Astou Dabo, Ndèye Fatou Sow, Djibril Wade, Souadou Ndoye, Abdoul Khoudoss Diallo, Anna Julienne Selbé Ndiaye, Yacine Amet Dia, Gora Lô, Abdoulaye Diallo, Ousmane M. Diop, Aminata Mboup, Ambroise D. Ahouidi, Papa Alassane Diaw, Badara Cissé, Moustapha Mbow, Makhtar Camara, Ndèye Coumba Touré Kâne, Souleymane Mboup,

Immune responses and vaccinations

Background: Vaccination against SARS-CoV-2 is currently the best preventive measure to control the COVID-19 pandemic. However, in some cases, it appeared that despite the vaccination, some people were reinfected. Aim: The objective of this study is to monitor preliminary data of COVID-19 reinfection cases in vaccinated individuals in Senegal. Methods: In this study, we used the Oxford Nanopore MinION portable sequencer as detailed in the ARTIC network to test SARS-CoV-2 positive samples from reinfected patients. A total of 71 subjects were monitored with 37 vaccinated patients and 34 non-vaccinated and samples were sequenced in genomic platform at IRESSEF. Results: We noted the presence of three major lineages B.1.617.2, AY4 and AY34 in vaccinated people. In addition, the mutation W152R and two other mutations never described (T1136S and V1137L) were found in tested genomic sequences. Conclusion: These results will contribute to monitor future epidemics and to control the effectiveness of the vaccination against COVID-19 especially the Variant of Concern and allow us to improve surveillance for COVID-19 pandemic.