Whole-heart computational modelling provides further mechanistic insights into ST-elevation in Brugada syndrome
2024; Elsevier BV; Volume: 51; Linguagem: Inglês
10.1016/j.ijcha.2024.101373
ISSN2352-9067
AutoresEike M. Wülfers, Robin Moss, Heiko Lehrmann, Thomas Arentz, Dirk Westermann, Gunnar Seemann, Katja E. Odening, Johannes Steinfurt,
Tópico(s)ECG Monitoring and Analysis
ResumoBrugada syndrome (BrS) is characterized by dynamic ST-elevations in right precordial leads and increased risk of ventricular fibrillation and sudden cardiac death. As the mechanism underlying ST-elevation and malignant arrhythmias is controversial computational modeling can aid in exploring the disease mechanism. Thus we aim to test the main competing hypotheses ('delayed depolarization' vs. 'early repolarization') of BrS in a whole-heart computational model.
Referência(s)