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Modulation of diabetic wound healing using carbon monoxide gas-entrapping materials

2024; Elsevier BV; Volume: 2; Issue: 5 Linguagem: Inglês

10.1016/j.device.2024.100320

2666-9986

Emily Witt, Alexander J. Leach, Jianling Bi, Samual Hatfield, Alicia T. Cotoia, Megan K. McGovern, Arielle B. Cafi, Ashley C. Rhodes, Austin N. Cook, Slyn Uaroon, Bishal Parajuli, Jinhee Kim, Vivian R. Feig, Alexandra Scheiflinger, Ikenna Nwosu, Miguel Jiménez, Mitchell C. Coleman, Marisa R. Buchakjian, Dustin E. Bosch, Michael S. Tift, Giovanni Traverso, Leo E. Otterbein, James D. Byrne,

Diabetic Foot Ulcer Assessment and Management

Diabetic wound healing is uniquely challenging to manage due to chronic inflammation and heightened microbial growth from elevated interstitial glucose. Carbon monoxide (CO), widely acknowledged as a toxic gas, is also known to provide unique therapeutic immune-modulating effects. To facilitate delivery of CO, we have designed hyaluronic-acid-based CO gas-entrapping materials (CO-GEMs) for topical and prolonged gas delivery to the wound bed. We demonstrate that CO-GEMs promote the healing response in murine diabetic wound models (full-thickness wounds and pressure ulcers) compared to N2-GEMs and untreated controls.